Evidence map›Paper›PMID 37821234›Full record

ArticleNeurology2023

Major Surgery, Brain Injury, and Neurodevelopmental Outcomes in Very Preterm Infants.

Thiviya Selvanathan, Stephanie H Au-Young, Ting Guo, Vann Chau, Helen M Branson, Anne Synnes, Linh Ly, Edmond N Kelly, Ruth E Grunau, Steven P Miller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Thiviya SelvanathanFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-3288-2434
Stephanie H Au-YoungFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0009-0003-5285-4841
Ting GuoFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.
Vann ChauFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-8260-8738
Helen M BransonFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.
Anne SynnesFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.
Linh LyFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.
Edmond N KellyFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0003-0271-4720
Ruth E GrunauFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada.
Steven P MillerFrom the Department of Pediatrics (T.S., S.H.A.-Y., T.G., V.C., L.L., E.N.K., S.P.M.), The Hospital for Sick Children and University of Toronto, Ontario; Department of Diagnostic Imaging (H.M.B.), The Hospital for Sick Children and Medical Imaging, University of Toronto, Ontario; Neonatology (E.N.K.), Mount Sinai Hospital, Toronto, Ontario; and Department of Pediatrics (A.S., R.E.G., S.P.M.), BC Women's & Children's Hospitals and University of British Columbia, Vancouver, British Columbia, Canada. steven.miller@cw.bc.ca.ORCID 0000-0001-9102-9105
Hospital for Sick Children · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe determined whether (1) major surgery is associated with an increased risk for brain injury and adverse neurodevelopment and (2) brain injury modifies associations between major surgery and neurodevelopment in very preterm infants.

methodsProspectively enrolled infants across 3 tertiary neonatal intensive care units underwent early-life and/or term-equivalent age MRI to detect moderate-severe brain injury. Eighteen-month neurodevelopmental outcomes were assessed with Bayley Scales of Infant and Toddler Development, third edition. Multivariable logistic and linear regressions were used to determine associations of major surgery with brain injury and neurodevelopment, adjusting for clinical confounders.

resultsThere were 294 infants in this study. Major surgery was associated with brain injury (odds ratio 2.54, 95% CI 1.12-5.75, DISCUSSION: There is an increased risk for brain injury and adverse motor outcomes in very preterm infants who require major surgery, which may be a marker of clinical illness severity. Routine brain MRI to detect brain injury and close neurodevelopmental surveillance should be considered in this subgroup of infants.

Indexed as

Brain InjuriesInfant, Premature, DiseasesNeurodevelopmental DisordersBrainHumansInfantInfant, NewbornInfant, Premature

Identifiers

PMID37821234
PMCPMC10663038
OpenAlexW4387524844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.