Evidence map›Paper›PMID 37821139›Full record

ArticleBMJ open2023

EMPOWERED trial: protocol for a randomised control trial of digitally supported, highly personalised and measurement-based care to improve functional outcomes in young people with mood disorders.

Ian B Hickie, Frank Iorfino, Cathrin Rohleder, Yun Ju Christine Song, Alissa Nichles, Natalia Zmicerevska, William Capon, Adam J Guastella, F Markus Leweke, Jan Scott and 17 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Observational
  3. A prognostic model for predicting functional impairment in youth mental health services.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 3 countries.

Ian B HickieBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Frank IorfinoBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia frank.iorfino@sydney.edu.au.ORCID 0000-0003-1109-0972
Cathrin RohlederBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Yun Ju Christine SongBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Alissa NichlesBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0001-6404-7199
Natalia ZmicerevskaBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0001-7649-4711
William CaponBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0001-6500-9629
Adam J GuastellaBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0001-8178-4625
F Markus LewekeBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Jan ScottNewcastle University, Newcastle upon Tyne, UK.ORCID 0000-0002-7203-8601
Patrick McGorryCentre for Youth Mental Health, University of Melbourne Australia, Parkville, Victoria, Australia.
Cathrine MihalopoulosSchool of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia.
Eoin KillackeyCentre for Youth Mental Health, University of Melbourne Australia, Parkville, Victoria, Australia.
Min K ChongBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0003-4562-731X
Sarah McKennaBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-8560-6399
Melissa AjiBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Carla GorbanBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Jacob J CrouseBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.ORCID 0000-0002-3805-2936
Dagmar KoetheBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Robert BattistiMind Plasticity, Sydney, New South Wales, Australia.
Blake HamiltonBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
Alice LoMind Plasticity, Sydney, New South Wales, Australia.
Maree L HackettGeorge Institute for Global Health, Newtown, New South Wales, Australia.ORCID 0000-0003-1211-9087
Daniel F HermensThompson Institute, University of the Sunshine Coast, Birtinya, Queensland, Australia.
Mind Plasticity Consortia
headspace Camperdown Consortia
Elizabeth M ScottBrain and Mind Centre, The University of Sydney, Camperdown, New South Wales, Australia.
The University of Sydney · AUMind Australia · AUThe University of Melbourne · AUMonash University · AUNewcastle University · GBThe George Institute for Global Health · AUUniversity of the Sunshine Coast · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMany adolescents and young adults with emerging mood disorders do not achieve substantial improvements in education, employment, or social function after receiving standard youth mental health care. We have developed a new model of care referred to as 'highly personalised and measurement-based care' (HP&MBC). HP&MBC involves repeated assessment of multidimensional domains of morbidity to enable continuous and personalised clinical decision-making. Although measurement-based care is common in medical disease management, it is not a standard practice in mental health. This clinical effectiveness trial tests whether HP&MBC, supported by continuous digital feedback, delivers better functional improvements than standard care and digital support. METHOD AND ANALYSIS: This controlled implementation trial is a PROBE study (Prospective, Randomised, Open, Blinded End-point) that comprises a multisite 24-month, assessor-blinded, follow-up study of 1500 individuals aged 15-25 years who present for mental health treatment. Eligible participants will be individually randomised (1:1) to 12 months of HP&MBC or standardised clinical care. The primary outcome measure is social and occupational functioning 12 months after trial entry, assessed by the Social and Occupational Functioning Assessment Scale. Clinical and social outcomes for all participants will be monitored for a further 12 months after cessation of active care. ETHICS AND DISSEMINATION: This clinical trial has been reviewed and approved by the Human Research Ethics Committee of the Sydney Local Health District (HREC Approval Number: X22-0042 & 2022/ETH00725, Protocol ID: BMC-YMH-003-2018, protocol version: V.3, 03/08/2022). Research findings will be disseminated through peer-reviewed journals, presentations at scientific conferences, and to user and advocacy groups. Participant data will be deidentified. TRIAL REGISTRATION NUMBER: ACTRN12622000882729.

Indexed as

Mental HealthMood DisordersAdolescentFollow-Up StudiesHumansProspective StudiesRandomized Controlled Trials as TopicTreatment OutcomeYoung Adultclinical trialsmental healthpsychiatry

Identifiers

PMID37821139
PMCPMC10583041
OpenAlexW4387527258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.