Trial reportBiological psychiatry. Cognitive neuroscience and neuroimaging2024
Changes in Brain Network Connections After Exposure and Response Prevention Therapy for Obsessive-Compulsive Disorder in Adolescents and Adults.
Trial report in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Functional connectivity changes in obsessive-compulsive disorder following exposure and response prevention.Translational psychiatry · 2026Article
- Neurofeedback interventions for obsessive-compulsive and related disorders: Current evidence and future directions.Journal of psychiatric research · 2026Review
- Sex-specific alterations of intrinsic brain activity and functional connectivity in adolescent obsessive-compulsive disorder.Medical & biological engineering & computing · 2026Article
- Functional Connectivity Fingerprints of Emerging Reading Skill in the First Months of Schooling.Developmental science · 2026Article
- Connectivity between the central executive and salience networks normalizes with exposure-focused CBT in pediatric anxiety.medRxiv : the preprint server for health sciences · 2026Article
- The Speech Network in Childhood Stuttering: Differences in Functional Connectivity of the Planning and Motor Loops.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Neuroimaging as a Tool for Advancing Pediatric Psychopharmacology.Paediatric drugs · 2025Review
- Brain Network Abnormalities in Obsessive-Compulsive Disorder: Insights from Edge Functional Connectivity Analysis.Behavioral sciences (Basel, Switzerland) · 2025Article
- Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis.Frontiers in psychiatry · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFunctional alterations of tripartite neural networks during cognitive control (i.e., frontoparietal network [FPN], cingulo-opercular network, and default mode network) occur in patients with obsessive-compulsive disorder (OCD) and may contribute to illness expression. However, the degree to which changes in these networks are elicited by gold standard treatment (e.g., exposure and response prevention [EX/RP]) remains unknown. Understanding how EX/RP modulates network connectivity in adolescent versus adult patients with OCD may aid the identification of developmentally sensitive treatment targets that enhance cognitive control.
methodsData from a total of 169 adolescents (13-17 years) and adults (25-40 years; 57% female) were analyzed, including healthy control participants (n = 58) and patients with OCD (n = 111) who were randomized to either EX/RP or an active control therapy (stress management training). Participants performed a flanker task during functional magnetic resonance imaging pre- and posttreatment. To retain sensitivity to individual differences in connectivity, group iterative multiple model estimation was used to assess functional connectivity (i.e., density) within and between brain networks.
resultsSignificant increases in FPN density and decreases in FPN-default mode network density were observed from pre- to posttreatment in patients who received EX/RP. The opposite patterns of change occurred in patients who received stress management training. These treatment-related changes in network density did not differ across age group.
conclusionsResults suggest EX/RP-specific changes in task-based connectivity in patients with OCD. Given baseline differences between healthy control participants and patients by age group, these treatment-related changes may indicate restoration of healthy FPN and default mode network development across patients, providing targets for improving response to EX/RP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.