ArticleBiofabrication2023
Human vascularized bile duct-on-a chip: a multi-cellular micro-physiological system for studying cholestatic liver disease.
Open access · hybridAbstract read
In one paragraph
Article in Biofabrication, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 22 citations in OpenAlex.
- Cholangiocyte biology in primary sclerosing cholangitis and other cholangiopathies: pathogenesis, clinical insights, and experimental tools.Physiological reviews · 2026Review
- Human organoids: Fit for drug discovery?Stem cell reports · 2026Review
- Transformative biomechanics and mechanobiology breakthroughs shaping the future of health and medicine.Innovation (Cambridge (Mass.)) · 2026Review
- Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips.Advanced biology · 2026Review
- Collagen Type I as a Biological Barrier Interface in Biomimetic Microfluidic Devices: Properties, Applications, and Challenges.Biomimetics (Basel, Switzerland) · 2026Review
- Integrating mechanical cues inFrontiers in immunology · 2026Review
- Spatial patterning strategies for liver tissue engineering: Biofabrication technologies and applications.Advanced drug delivery reviews · 2026Review
- Protocol for fabricating a vascularized bile duct-on-a-chip.Biophysics reports · 2025Article
- Article
- Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2Journal of nanobiotechnology · 2025Article
- Bile acid metabolism in type 2 diabetes mellitus.Nature reviews. Endocrinology · 2025Review
- 3D bioprinting for bile duct tissue engineering: current status and prospects.Frontiers in bioengineering and biotechnology · 2025Review
- Biomedical applications of organoids derived from the digestive system.Frontiers in cell and developmental biology · 2025Review
- 3D Bioprinting for Engineered Tissue Constructs and Patient-Specific Models: Current Progress and Prospects in Clinical Applications.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Liver-on-chips for drug discovery and development.Materials today. Bio · 2024Review
- Biliary atresia.Nature reviews. Disease primers · 2024Review
- Human Hepatobiliary Organoids: Recent Advances in Drug Toxicity Verification and Drug Screening.Biomolecules · 2024Review
- Donor-Derived Engineered Microvessels for Cardiovascular Risk Stratification of Patients with Kidney Failure.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Vascular microphysiological systems.Current opinion in hematology · 2024Review
- The utilisation of biliary organoids for biomedical applications.Frontiers in bioengineering and biotechnology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Yu DuDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0003-1406-1376
Iris E M de JongDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Kapish GuptaDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Orit Waisbourd-ZinmanInstitute for Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Adi Har-ZahavInstitute for Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Carol J SorokaDepartment of Internal Medicine, Section of Digestive Diseases and Liver Center, Yale University School of Medicine, New Haven, CT, United States of America.
James L BoyerDepartment of Internal Medicine, Section of Digestive Diseases and Liver Center, Yale University School of Medicine, New Haven, CT, United States of America.
Jessica LlewellynDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Chengyang LiuDepartment of Surgery, University of Pennsylvania, Philadelphia, PA, United States of America.
Ali NajiDepartment of Surgery, University of Pennsylvania, Philadelphia, PA, United States of America.
William J PolacheckJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, United States of America.
Rebecca G WellsDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.ORCID 0000-0002-6988-4102
University of Pennsylvania · USTel Aviv University · ILYale University · USInstitute of Mechanics · BGUniversity of North Carolina at Chapel Hill · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MHuman Pancreas Analysis Program for Type 1 Diabetes - HPAP-T1DU01DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MARK A. ATKINSON, KLAUS H KAESTNER · 2021 to 2026
$46.8MTranslational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3MTRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 1997 to 2026
$32.5MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MInjury, Progression, and Fibrosis of the Extrahepatic Bile DuctR01DK119290 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 2019 to 2026
$2.9MNCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK119290NIDDK NIH HHS U01 DK112217NIEHS NIH HHS P30 ES013508
Abstract
Exploring the pathogenesis of and developing therapies for cholestatic liver diseases such as primary sclerosing cholangitis (PSC) remains challenging, partly due to a paucity of
Indexed as
Cholangitis, SclerosingLiver DiseasesBile DuctsEndothelial CellsHumansLeukocytes, MononuclearSignal Transductioncholangiopathymicrofluidic deviceorgan-on-a-chipprimary sclerosing cholangitistissue engineering
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.