Trial reportAmerican journal of respiratory and critical care medicine2023
Early Video-assisted Thoracoscopic Surgery or Intrapleural Enzyme Therapy in Pleural Infection: A Feasibility Randomized Controlled Trial. The Third Multicenter Intrapleural Sepsis Trial-MIST-3.
Open access · hybridAbstract readRandomized Controlled TrialClinical Trial, Phase IIIMulticenter Study
In one paragraph
Trial report in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
- The LTI-01-2001 phase 2a trial of intrapleural LTI-01 in patients with infected, non-draining pleural effusions.Respiratory research · 2026Trial
- A Parallel Group, 1:1 Randomised, Pilot Study Comparing the Clinical Efficacy and Bleeding Risk Between Low Dose and Standard Dose Intrapleural Tissue Plasminogen Activator for Adults With Pleural Infection.Respirology case reports · 2026Trial
- A pilot randomised, open label controlled trial comparing safety and efficacy of pleural irrigation with normal saline versus intrapleural tissue plasminogen activator and DNase (fibrinolytic therapy) in pleural infection.BMC pulmonary medicine · 2026Trial
- First-line medical thoracoscopy for pleural infection: the SPIRIT randomised controlled feasibility trial.BMJ open respiratory research · 2025Trial
- Evidence-based, cost-effective management of empyema and chylothorax: An algorithm of the Journal of Trauma and Acute Care Surgery Emergency General Surgery Algorithms work group.The journal of trauma and acute care surgery · 2026Article
- Article
- Pleural fluid neutrophil extracellular traps are associated with disease severity and risk of 1-year mortality in pleural infection: an observational, international, multicohort study (TORPIDS-3).The European respiratory journal · 2026Observational
- Rheumatoid Pleuropulmonary Disease Mimicking Refractory Empyema: A Diagnostic Challenge With Trapped Lung.Cureus · 2026Article
- Long-term cardiopulmonary function in children treated for empyema: comparison of chest drain with fibrinolytics and video-assisted thoracoscopic surgery.BMJ open respiratory research · 2026Article
- Intrapleural fibrinolytic therapy for pleural infection: a multicentre real-world comparison of dosing regimens.Journal of thoracic disease · 2026Article
- WABIP/AABIP statement on therapeutic indications of medical thoracoscopy for benign pleural disease.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Managing pleural infections: a nationwide survey of respiratory physicians in Singapore.BMJ open respiratory research · 2026Article
- Review
- Local management of pleural infection: a narrative review.European journal of medical research · 2026Review
- What is new in pleural infections?Breathe (Sheffield, England) · 2026Review
- Italian multicentre study on the management of pLeural infection and empyema: IMPLE study.Respiratory research · 2025Observational
- Patient perspectives and priorities in pleural infection: results of the MIST-3 feasibility trial qualitative substudy.ERJ open research · 2025Article
- INHIBITING THE INHIBITOR: WOULD TARGETING PAI-1 RESULT IN A LOW-DOSE, WELL-TOLERATED TREATMENT OF EMPYEMA?Biomedical sciences instrumentation · 2025Article
- Surgical interventions for pleural infection.Breathe (Sheffield, England) · 2025Review
- Patient Preferences in empYema treatment (PAPY-study): are we investigating relevant outcomes for patients?Journal of thoracic disease · 2025Article
Corrections and comments
- Commented on by
Authors and funding
40 authors at 20 institutions in 9 countries.
Eihab O BedawiOxford Respiratory Trials Unit, Nuffield Department of Medicine.ORCID 0000-0001-9196-3934
Dionisios StavrouliasDepartment of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom.
Emma HedleyOxford Respiratory Trials Unit, Nuffield Department of Medicine.
Kevin G BlythSchool of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.
Alan KirkDepartment of Thoracic Surgery, Golden Jubilee National Hospital, Glasgow, United Kingdom.
Duneesha De FonsekaAcademic Directorate of Respiratory Medicine.
John G EdwardsDepartment of Thoracic Surgery, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
Eveline InternulloDepartment of Thoracic Surgery, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
John P CorcoranDepartment of Respiratory Medicine and.
Adrian MarchbankDepartment of Cardiothoracic Surgery, Derriford Hospital, University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.
Rakesh PanchalDepartment of Respiratory Medicine, Glenfield Hospital, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
Edward CaruanaDepartment of Thoracic Surgery, Glenfield Hospitals, University Hospitals of Leicester, Leicester, United Kingdom.
Owais KadwaniDepartment of Respiratory Medicine and.
Lawrence OkirorDepartment of Thoracic Surgery, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Tarek SabaDepartment of Respiratory Medicine and.
Manoj PurohitDepartment of Cardiothoracic Surgery, Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, United Kingdom.
Rachel M MercerPortsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom.
Rhona TaberhamDepartment of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom.
Nikolaos KanellakisOxford Respiratory Trials Unit, Nuffield Department of Medicine.
Alison M CondliffeDepartment of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
Leon G LewisAcademic Directorate of Respiratory Medicine.
Dinesh N AddalaOxford Respiratory Trials Unit, Nuffield Department of Medicine.
Rachelle AsciakPortsmouth Hospitals NHS Trust, Queen Alexandra Hospital, Portsmouth, United Kingdom.
Radhika BankaDepartment of Respiratory Medicine, PD Hinduja National Hospital, Mumbai, India.
Vineeth GeorgeDepartment of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, New South Wales, Australia.
Maged HassanChest Diseases Department, Alexandria University, Alexandria, Egypt.ORCID 0000-0002-8768-6548
David McCrackenRoyal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, Northern Ireland.
Anand SundaralingamOxford Respiratory Trials Unit, Nuffield Department of Medicine.
John M WrightsonOxford Respiratory Trials Unit, Nuffield Department of Medicine.
Melissa DobsonOxford Respiratory Trials Unit, Nuffield Department of Medicine.
Alex WestDepartment of Respiratory Medicine and.
Graham BarnesPatient representative, Oxford, United Kingdom.
John HarveyDepartment of Respiratory Medicine, North Bristol NHS Trust, Bristol, United Kingdom.
Mark SladeDepartment of Respiratory Medicine, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, United Kingdom; and.
Mae Chester-JonesOxford Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom.
Susan DuttonOxford Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom.
Robert F MillerInstitute for Global Health, University College London, London, United Kingdom.
Nick A MaskellDepartment of Respiratory Medicine, North Bristol NHS Trust, Bristol, United Kingdom.
Elizabeth BelcherDepartment of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford University Hospitals National Health Service (NHS) Foundation Trust, Oxford, United Kingdom.
Najib M RahmanOxford Respiratory Trials Unit, Nuffield Department of Medicine.
Nuffield Orthopaedic Centre · GBDirectorate of Health · ISNational Health Service · GBSt Thomas' Hospital · GBBlackpool Teaching Hospitals NHS Foundation Trust · GBChinese Academy of Medical Sciences & Peking Union Medical College · CNGlenfield Hospital · GBNorth Bristol NHS Trust · GBOffice for National Statistics · GBQueen Alexandra Hospital · GBAlexandria University · EGBeatson West of Scotland Cancer Centre · GBBelfast Health and Social Care Trust · GBDerriford Hospital · GBGloucestershire Hospitals NHS Foundation Trust · GBHouse of Representatives · NLJohn Hunter Hospital · AUP. D. Hinduja Hospital and Medical Research Centre · INQueen Elizabeth University Hospital · GBSheffield Teaching Hospitals NHS Foundation Trust · GB
Funding
Research for Patient Benefit Programme PG-PB-0416-20020
Abstract
PubMed holds no abstract for this paper.
Indexed as
Communicable DiseasesPleural DiseasesSepsisEnzyme TherapyFeasibility StudiesHumansThoracic Surgery, Video-Assistedintrapleuralpleural effusionpleural empyemarandomized controlled trialvideo-assisted thoracic surgery
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.