Evidence map›Paper›PMID 37820028›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Spatiotemporal Control over Polynucleotide Brush Growth on DNA Origami Nanostructures.

Yunqi Yang, Qinyi Lu, Yu Chen, Marcello DeLuca, Gaurav Arya, Yonggang Ke, Stefan Zauscher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yunqi YangDepartment of Mechanical Engineering and Materials Science, Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Qinyi LuDepartment of Chemistry, Emory University, Atlanta, GA 30322, USA.
Yu ChenUniversity Program in Materials Science and Engineering, Duke University, Durham, NC 27708, USA.
Marcello DeLucaDepartment of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Gaurav AryaDepartment of Mechanical Engineering and Materials Science, Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Yonggang KeDepartment of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA.
Stefan ZauscherDepartment of Mechanical Engineering and Materials Science, Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.ORCID 0000-0002-2290-7178

Funding

In situ Enzymatic Synthesis of Aptamer Targeted Polynucleotide Drug Nanoparticles for Cancer TherapyR21EB026590 · NIBIB · DUKE UNIVERSITY · PI ZAUSCHER, STEFAN · 2018 to 2020
$621k
NIBIB NIH HHS R21 EB026590NIBIB NIH HHS R21 EB026590-03
6 · The paper itself

Abstract

DNA nanotechnology provides an approach to create precise, tunable, and biocompatible nanostructures for biomedical applications. However, the stability of these structures is severely compromised in biological milieu due to their fast degradation by nucleases. Recently, we showed how enzymatic polymerization could be harnessed to grow polynucleotide brushes of tunable length and location on the surface of DNA origami nanostructures, which greatly enhances their nuclease stability. Here, we report on strategies that allow for both spatial and temporal control over polymerization through activatable initiation, cleavage, and regeneration of polynucleotide brushes using restriction enzymes. The ability to site-specifically decorate DNA origami nanostructures with polynucleotide brushes in a spatiotemporally controlled way provides access to "smart" functionalized DNA architectures with potential applications in drug delivery and supramolecular assembly.

Indexed as

NanostructuresPolynucleotidesDNADrug Delivery SystemsNanotechnologyNucleic Acid ConformationDNAPolynucleotidesDNA NanostructuresRestriction EnzymesSequential Brush GrowthSurface-Initiated PolymerizationTerminal Deoxynucleotidyl Transferase

Identifiers

PMID37820028
PMCPMC12226241

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.