Evidence map›Paper›PMID 37820006›Full record

ArticleScience translational medicine2023

Lactate oxidase nanocapsules boost T cell immunity and efficacy of cancer immunotherapy.

Zheng Cao, Duo Xu, Jeffrey Harding, Wenting Chen, Xiangsheng Liu, Zi Wang, Lan Wang, Tong Qi, Shilin Chen, Xinheng Guo and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
24.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Zheng CaoDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1242-3513
Duo XuDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-0483-8719
Jeffrey HardingUCLA AIDS Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Wenting ChenDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Xiangsheng LiuDivision of Nanomedicine, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5719-2838
Zi WangDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Lan WangUCLA AIDS Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Tong QiDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Shilin ChenDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Xinheng GuoDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Irvin S Y ChenUCLA AIDS Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1199-2415
Jimin GuoDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-8249-1880
Yunfeng LuDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-8589-0297
Jing WenUCLA AIDS Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-6127-6276
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9M
UCLA-CDU CFARP30AI152501 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2022 to 2026
$15.6M
In Vivo Gene Editing for HIV-1 CureR01AI145038 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, IRVIN S.Y. · 2019 to 2023
$3.4M
Targeting delivery of mAbs to CNS metastasesR01CA253215 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEN, JING · 2020 to 2024
$1.7M
An antioxidant enzyme to suppress hyperinflammation induced by SARS-CoV-2R56AI163386 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEN, JING · 2022 to 2022
$380k
NCATS NIH HHS UL1 TR001881NCI NIH HHS R01 CA253215NIAID NIH HHS P30 AI028697NIAID NIH HHS P30 AI152501NIAID NIH HHS R01 AI145038NIAID NIH HHS R56 AI163386
6 · The paper itself

Abstract

Cancer immunotherapy has reshaped the landscape of cancer treatment. However, its efficacy is still limited by tumor immunosuppression associated with the excessive production of lactate by cancer cells. Although extensive efforts have been made to reduce lactate concentrations through inhibition of lactate dehydrogenase, such inhibitors disrupt the metabolism of healthy cells, causing severe nonspecific toxicity. We report herein a nanocapsule enzyme therapeutic based on lactate oxidase, which reduces lactate concentrations and releases immunostimulatory hydrogen peroxide, averting tumor immunosuppression and improving the efficacy of immune checkpoint blockade treatment. As demonstrated in a murine melanoma model and a humanized mouse model of triple-negative breast cancer, this enzyme therapeutic affords an effective tool toward more effective cancer immunotherapy.

Indexed as

MelanomaNanocapsulesAnimalsImmunotherapyLactatesMiceMixed Function OxygenasesT-LymphocytesTumor Microenvironmentlactate 2-monooxygenaseLactatesMixed Function OxygenasesNanocapsules

Identifiers

PMID37820006
PMCPMC10720694
OpenAlexW4387526345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.