Evidence map›Paper›PMID 37819534›Full record

ArticleEJNMMI radiopharmacy and chemistry2023

Good practices for the automated production of

Simon Blok, Carmen Wängler, Peter Bartenstein, Klaus Jurkschat, Ralf Schirrmacher, Simon Lindner

Open access · goldAbstract read
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Aryl Sulfamoyl [Journal of medicinal chemistry · 2026
    Article
  2. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  3. Influence of Different Parameters on the Labeling Efficiency of Technetium-99m Radiopharmaceuticals: Kuwait Nuclear Medicine Departments Experiences.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Article
  4. Review
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Simon BlokDepartment of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Carmen WänglerBiomedical Chemistry, Clinic of Radiology and Nuclear Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Peter BartensteinDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Klaus JurkschatFakultät für Chemie und Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany.
Ralf SchirrmacherDepartment of Oncology, Division of Oncological Imaging, University of Alberta, Edmonton, AB, Canada. schirrma@ualberta.ca.ORCID http://orcid.org/0000-0002-7098-3036
Simon LindnerDepartment of Nuclear Medicine, LMU University Hospital, LMU Munich, Munich, Germany. simon.lindner@med.uni-muenchen.de.
LMU Klinikum · DEHeidelberg University · DETU Dortmund University · DEUniversity Medical Center Groningen · NLUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe positron emitting isotope fluorine-18 ( MAIN BODY: A radiotracer's clinical success primarily hinges on whether its synthesis can be automated. Due to its simplicity, the SiFA chemistry, which is based on isotopic exchange (

conclusionThis current review highlights the most recent achievements in SiFA radiopharmaceutical automation geared towards large batch production for clinical application. Best practice advice and guidance towards a facilitated implementation of the SiFA technology into new and already operating PET tracer production facilities is provided. A brief outlook spotlights the future potential of SiFA radiochemistry within the landscape of non-canonical labeling chemistries.

Indexed as

AutomationFluorine-18Positron emission tomography (PET)Silicon fluoride acceptor

Identifiers

PMID37819534
PMCPMC10567618
OpenAlexW4387518394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.