Evidence map›Paper›PMID 37819161›Full record

ArticleThe Journal of manual & manipulative therapy2024

Specific and shared mechanisms associated with treatment for chronic neck pain: study protocol for the SS-MECH trial.

Chad E Cook, Bryan O'Halloran, Amy McDevitt, Francis J Keefe

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of manual & manipulative therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06361472 (A Two-Center, Investigator-Blinded, Randomized, 4-Week, Parallel-Group, Superiority Study Comparing Contextual Factors-Enriched Standard Care Versus Standard Care Only for Patients With Mechanical Neck Pain), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06361472 narecruitingnot on this map

A Two-Center, Investigator-Blinded, Randomized, 4-Week, Parallel-Group, Superiority Study Comparing Contextual Factors-Enriched Standard Care Versus Standard Care Only for Patients With Mechanical Neck Pain (ContextualizAR Trial)

TypeinterventionalSponsorUniversidad Nacional de la MatanzaRan2024 to 2027Enrolled94ConditionsNeck PainArmsStandard Care, Contextual Factors
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chad E CookDepartment of Physical Therapy, School of Health Professions, Saint Joseph's University, Philadelphia, PA, USA.
Bryan O'HalloranDepartment of Orthopaedic Surgery, Duke University, Durham, NC, USA.
Amy McDevittDepartment of Population Health Sciences, Duke University, Durham, NC, USA.
Francis J KeefeDuke Clinical Research Institute, Duke University, Durham, NC, USA.

Funding

Force-Based Manipulations Research NetworkU24AT011969 · NCCIH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Chad Cook, William Ray Reed · 2022 to 2026
$2.6M
NCCIH NIH HHS U24 AT011969
6 · The paper itself

Abstract

backgroundTreatment mechanisms involve the steps or processes through which an intervention unfolds and produces change in an outcome variable. Treatment mechanisms can be specific to the intervention provided (i.e. pain modulation) or shared with other treatments (i.e. reduced fear of movement). Whether specific and shared treatment mechanisms are different across interventions and whether they lead to the outcomes seen in trials is largely unknown. The management of individuals with chronic neck pain routinely include manual therapy (MT) and resistance exercise (RE), as both approaches are included in clinical practice guidelines and both yield similar outcomes.

objectivesOur study plans to answer two research questions: 1) what are the specific mechanisms associated with MT versus interventions (and are these different), and 2) what are the shared mechanisms associated with these interventions, and do specific or shared mechanisms mediate clinical outcomes?

methodsThis study will involve a 2-group parallel (1:1) single-blinded randomized trial to compare the specific and potential shared treatment mechanisms between these two approaches. We will enroll individuals with a history of chronic neck pain and evaluate whether specific or shared mechanisms mediate clinical outcomes.

resultsWe hypothesize that MT and RE approaches will both exhibit different specific treatment mechanisms, and that both approaches will exhibit shared treatment mechanisms, which will notably influence outcomes at both discharge and 6-months.

conclusionsThis study is important because it will help identify what specific or shared treatment mechanisms are associated with different interventions and, how different treatment mechanisms influence clinical outcomes.

Indexed as

Chronic PainMusculoskeletal ManipulationsExerciseExercise TherapyHumansNeck PainRandomized Controlled Trials as TopicManual therapyMechanismsNeck painPhysical therapy

Identifiers

PMID37819161
PMCPMC10795632

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.