Evidence map›Paper›PMID 37819123›Full record

ArticleMicrobiology resource announcements2023

T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix , GSK) vaccine strain.

Asha A Philip, Chantal A Agbemabiese, Guanghui Yi, John T Patton

Abstract read
In one paragraph

Article in Microbiology resource announcements, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Asha A PhilipDepartment of Biology, Indiana University Bloomington , Bloomington, Indiana, USA.
Chantal A AgbemabieseDepartment of Electron Microscopy and Histopathology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana , Accra, Ghana.ORCID 0000-0003-1862-9408
Guanghui YiDepartment of Biology, Indiana University Bloomington , Bloomington, Indiana, USA.
John T PattonDepartment of Biology, Indiana University Bloomington , Bloomington, Indiana, USA.ORCID 0000-0003-1572-0732

Funding

Rotavirus Vaccines Engineered as Vectors Against Other Enteric DiseasesR21AI144881 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI PATTON, JOHN THOMAS · 2019 to 2020
$413k
NIAID NIH HHS R21 AI144881
6 · The paper itself

Abstract

The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy.

Indexed as

recombinant virusreverse genetic analysisRIX4414 virusrotavirusvaccines

Identifiers

PMID37819123
PMCPMC10652971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.