Evidence map›Paper›PMID 37818354›Full record

ReviewFrontiers in immunology2023

Monitoring regulatory T cells as a prognostic marker in lung transplantation.

Mohammad Afzal Khan, Christine L Lau, Alexander Sasha Krupnick

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohammad Afzal KhanSchool of Medicine, University of Maryland, Baltimore, MD, United States.
Christine L LauSchool of Medicine, University of Maryland, Baltimore, MD, United States.
Alexander Sasha KrupnickSchool of Medicine, University of Maryland, Baltimore, MD, United States.

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI ALEXANDER S. KRUPNICK · 2015 to 2026
$19.4M
The Role of Eosinophils in the Lung AllograftR01AI145108 · NIAID · UNIVERSITY OF VIRGINIA · PI Elizabeth A Jacobsen, ALEXANDER S. KRUPNICK · 2019 to 2026
$4.1M
Prevention of Lung Transplant Injury with Adenosine 2A Receptor AgonistR01HL128492 · NHLBI · UNIVERSITY OF VIRGINIA · PI LAU, CHRISTINE L · 2016 to 2020
$3.8M
Targeting a Defined Surgical Stress-Induced Inflammatory Pathway to Improve Peri-Operative OutcomesR01HL166402 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Elizabeth A Jacobsen, ALEXANDER S. KRUPNICK · 2023 to 2026
$2.2M
BLRD VA I01 BX002299NHLBI NIH HHS R01 HL128492NHLBI NIH HHS R01 HL166402NIAID NIH HHS P01 AI116501NIAID NIH HHS R01 AI145108
6 · The paper itself

Abstract

Lung transplantation is the major surgical procedure, which restores normal lung functioning and provides years of life for patients suffering from major lung diseases. Lung transplant recipients are at high risk of primary graft dysfunction, and chronic lung allograft dysfunction (CLAD) in the form of bronchiolitis obliterative syndrome (BOS). Regulatory T cell (Treg) suppresses effector cells and clinical studies have demonstrated that Treg levels are altered in transplanted lung during BOS progression as compared to normal lung. Here, we discuss levels of Tregs/FOXP3 gene expression as a crucial prognostic biomarker of lung functions during CLAD progression in clinical lung transplant recipients. The review will also discuss Treg mediated immune tolerance, tissue repair, and therapeutic strategies for achieving

Indexed as

Bronchiolitis ObliteransLung TransplantationGraft RejectionHumansPrognosisT-Lymphocytes, Regulatorybronchiolitis obliterans syndromechronic lung allograft dysfunctionimmune toleranceregulatory T celltissue repair

Identifiers

PMID37818354
PMCPMC10561299

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.