Evidence map›Paper›PMID 37818195›Full record

ReviewFrontiers in pharmacology2023

A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid.

Qiang Cao, Qi Wang, Xinyan Wu, Qi Zhang, Jinghan Huang, Yuquan Chen, Yanwei You, Yi Qiang, Xufeng Huang, Ronggao Qin and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 3 countries.

Qiang Cao *Department of Earth Sciences, Kunming University of Science and Technology, Kunming, China.
Qi Wang *Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China.
Xinyan Wu *College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Qi Zhang *Undergraduate Department, Taishan University, Taian, China.
Jinghan Huang *Undergraduate Department, Sichuan Conservatory of Music, Chengdu, China.
Yuquan ChenInstitute of Medical Information/Library, Chinese Academy of Medical Sciences, Beijing, China.
Yanwei YouDivision of Sports Science and Physical Education, Tsinghua University, Beijing, China.
Yi QiangDepartment of Earth Sciences, Kunming University of Science and Technology, Kunming, China.
Xufeng HuangFaculty of Dentistry, University of Debrecen, Debrecen, Hungary.
Ronggao QinDepartment of Earth Sciences, Kunming University of Science and Technology, Kunming, China.
Guangzhu CaoDepartment of Earth Sciences, Kunming University of Science and Technology, Kunming, China.
Kunming University of Science and Technology · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNJiangsu University · CNMacau University of Science and Technology · MOSichuan Agricultural University · CNSichuan Conservatory of Music · CNTaishan University · CNTsinghua University · CNUniversity of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leonurine refers to the desiccated aerial portion of a plant in the Labiatae family. The primary bioactive constituent of Leonurine is an alkaloid, Leonurine alkaloid (Leo), renowned for its substantial therapeutic efficacy in the treatment of gynecological disorders, in addition to its broad-spectrum antineoplastic capabilities. Over recent years, the pharmacodynamic mechanisms of Leo have garnered escalating scholarly interest. Leo exhibits its anticancer potential by means of an array of mechanisms, encompassing the inhibition of neoplastic cell proliferation, induction of both apoptosis and autophagy, and the containment of oncogenic cell invasion and migration. The key signal transduction pathways implicated in these processes include the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL), the Phosphoinositide3-Kinase/Serine/Threonine Protein Kinase (PI3K/AKT), the Signal Transducer and Activator of Transcription 3 (STAT3), and the Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase (MAP/ERK). This paper commences with an exploration of the principal oncogenic cellular behaviors influenced by Leo and the associated signal transduction pathways, thereby scrutinizing the mechanisms of Leo in the antineoplastic sequence of events. The intention is to offer theoretical reinforcement for the elucidation of more profound mechanisms underpinning Leo's anticancer potential and correlating pharmaceutical development.

Indexed as

anti-tumor mechanismsapoptosis and autophagyleonurinesignal transduction pathwaystumor cell proliferation and migration

Identifiers

PMID37818195
PMCPMC10560730
OpenAlexW4387004493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.