Evidence map›Paper›PMID 37818119›Full record

Review3 Biotech2023

Benefits of using polymeric nanoparticles in breast cancer treatment: a systematic review.

Joabe Lima Araújo, Julia Augusto Vieira, Mayla Dos Santos Silva, Alan Kelbis Oliveira Lima, Glecia Virgolino da Silva Luz, Marcella Lemos Brettas Carneiro, Ricardo Bentes Azevedo

Open access · greenAbstract readReview
In one paragraph

Review in 3 Biotech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Joabe Lima AraújoDepartment of Genetics and Morphology, Institute of Biological Sciences, Darcy Ribeiro University Campus, University of Brasília, Brasília-DF, 70910-900 Brazil.ORCID 0000-0002-4806-9192
Julia Augusto VieiraDepartment of Genetics and Morphology, Institute of Biological Sciences, Darcy Ribeiro University Campus, University of Brasília, Brasília-DF, 70910-900 Brazil.
Mayla Dos Santos SilvaPost-Graduate Program in Biomedical Engineering (PPGEB), Faculty of Gama, University of Brasilia, Special Area of Industry Projection A, Brasília, 72444-240 Brazil.
Alan Kelbis Oliveira LimaDepartment of Genetics and Morphology, Institute of Biological Sciences, Darcy Ribeiro University Campus, University of Brasília, Brasília-DF, 70910-900 Brazil.
Glecia Virgolino da Silva LuzPost-Graduate Program in Biomedical Engineering (PPGEB), Faculty of Gama, University of Brasilia, Special Area of Industry Projection A, Brasília, 72444-240 Brazil.
Marcella Lemos Brettas CarneiroPost-Graduate Program in Biomedical Engineering (PPGEB), Faculty of Gama, University of Brasilia, Special Area of Industry Projection A, Brasília, 72444-240 Brazil.
Ricardo Bentes AzevedoDepartment of Genetics and Morphology, Institute of Biological Sciences, Darcy Ribeiro University Campus, University of Brasília, Brasília-DF, 70910-900 Brazil.
Universidade de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer comprises approximately 20% of all malignant neoplasm cases globally. Due to the limitations associated with conventional therapeutic approaches, extensive investigations have been undertaken to develop novel treatments that exhibit enhanced specificity and minimized adverse effects. Consequently, the application of polymeric nanoformulations for targeted drug delivery has gained significant attention within the biomedical field. Therefore, the primary objective of this study was to explore the inherent advantages and efficacy of employing polymeric nanoformulations for drug delivery in breast cancer treatment, as compared to traditional therapies. A comprehensive literature search was conducted across prominent databases including PubMed/MEDLINE, Embase, and Scopus, utilizing specific search strings. This meticulous approach yielded a total of 12 relevant articles for in-depth analysis and discussion. The findings from the selected studies underscore the effectiveness of employing polymeric nanoparticles as a drug delivery strategy, showcasing noteworthy improvements in cellular uptake and sustained intracellular retention of encapsulated therapeutic agents. Additionally, these nanoformulations exhibited superior efficacy, safety, and drug delivery capabilities. The utilization of polymeric nanoparticles in drug delivery has demonstrated a substantial enhancement in treatment efficacy, with the ability to achieve higher concentrations of active ingredients within tumor tissues, augment cellular uptake and drug concentrations, and sustain intracellular retention. Consequently, this innovative approach prolongs drug release in lower quantities, ultimately contributing to improved treatment outcomes.

Indexed as

Breast cancerDrug delivery systemDrug utilizationNanoparticles

Identifiers

PMID37818119
PMCPMC10560654
OpenAlexW4387456102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.