ArticleProceedings of SPIE--the International Society for Optical Engineering
Automated Tubular Morphometric Visualization for Whole Kidney Biopsy.
Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Reappraising Kidney Biopsy in Diabetic Kidney Disease: Histopathology, Clinical Course, and the Future of Precision Nephrology.Journal of clinical medicine · 2026Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
One of the strongest prognostic predictors of chronic kidney disease is interstitial fibrosis and tubular atrophy (IFTA). The ultimate goal of IFTA calculation is an estimation of the functional nephritic area. However, the clinical gold standard of estimation by pathologist is imprecise, primarily due to the overwhelming number of tubules sampled in a standard kidney biopsy. Artificial intelligence algorithms could provide significant benefit in this aspect as their high-throughput could identify and quantitatively measure thousands of tubules in mere minutes. Towards this goal, we use a custom panoptic convolutional network similar to Panoptic-DeepLab to detect tubules from 87 WSIs of biopsies from native diabetic kidneys and transplant kidneys. We measure 206 features on each tubule, including commonly understood features like tubular basement membrane thickness and tubular diameter. Finally, we have developed a tool which allows a user to select a range of tubule morphometric features to be highlighted in corresponding WSIs. The tool can also highlight tubules in WSI leveraging multiple morphometric features through selection of regions-of-interest in a uniform manifold approximation and projection plot.
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Registered trials
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