ArticleThe Saudi dental journal2023
Nanohydroxyapatite in dentistry: A comprehensive review.
Article in The Saudi dental journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bioactive inorganic materials in dental resin infiltrants: a systematic and critical review of their effects on infiltrant properties and tooth surfaces.Clinical oral investigations · 2025Pooled it
- Effect of remineralization after in office followed by home treatment of white spot lesions in children randomized controlled trial.Scientific reports · 2025Trial
- Efficacy of Fluoride Toothpaste Fortified With Micro- and Nano-Hydroxyapatite on Remineralization and Surface Roughness of Synthetic Enamel.Clinical and experimental dental research · 2026Article
- Biomimetic Enamel Remineralization in Pediatric Dentistry: From Biological Principles to Clinical Evidence.Cureus · 2026Review
- In vitro evaluation of a novel self-adhesive composite primer modified with nano zinc oxide and hydroxyapatite: antibacterial activity, marginal microleakage, and interfacial elemental analysis.BMC oral health · 2026Article
- Protective and remineralizing capacity of biosilicate, chitosan-based material, and fluoride on demineralized and irradiated enamel.Radiation and environmental biophysics · 2026Article
- Clinical Status and Salivary aMMP-8 Evaluation of 0.12% Chlorhexidine Versus MicroRepairDentistry journal · 2026Article
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Mini review on the synthesis of porous hydroxyapatite nanomaterials for dental tissue engineering.RSC advances · 2026Review
- Article
- Development of a Bioactive Dental Barrier Membrane Based on PCL/Collagen and PVA/Hydroxyapatite Layers with Amoxicillin-Loaded Electrosprayed Coating.Pharmaceutics · 2026Article
- Effect of incorporating chitosan/hydroxyapatite composite nanoparticles into a universal adhesive on bonding efficacy to caries-affected dentin and bioactivity.BMC oral health · 2026Article
- Comparative Evaluation of Clinical and Radiographic Success Rates of Direct Pulp Capping in Primary Molars Using TheraCal LC, 3Mixtatin, and Nanohydroxyapatite: AnInternational journal of clinical pediatric dentistry · 2026Article
- Preparation of clove extract-loaded nano-hydroxyapatite for combating dental caries-associated microbes.The Saudi dental journal · 2026Article
- Surface Roughness and Color Stability of Conventional Glass Ionomer Cement Reinforced With a Nanofiller Synthesized by the Coprecipitation Method.International journal of biomaterials · 2026Article
- Optical Coherence Tomography, Stereomicroscopic, and Histological Aspects of Bone Regeneration on Rat Calvaria in the Presence of Bovine Xenograft or Titanium-Reinforced Hydroxyapatite.Journal of functional biomaterials · 2026Article
- Evaluation of an orthodontic adhesive containing 2 wt% nano-hydroxyapatite synthesized from a biogenic calcium precursor: antibacterial activity, calcium ion concentration, and enamel demineralization.Biomaterial investigations in dentistry · 2026Article
- Sustainable Valorization of Mussel Shell Waste: Processing for Calcium Carbonate Recovery and Hydroxyapatite Production.Journal of functional biomaterials · 2025Article
- Synthesis, characterization and evaluation of novel bleaching gels containing bioactive glass and nano-hydroxyapatite on hydrogen peroxide diffusion, bleaching efficacy and enamel protection.Clinical oral investigations · 2025Article
- In vitro study on the bacteriostatic effect of Amoxicillin-loaded Nano-hydroxyapatite and its capability in occluding dentinal tubules.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enamel, being the hardest and the highest mineralized tissue of the human body, contains nearly 96% inorganic components and 4% organic compounds and water. Dentin contains 65% inorganic components and 35% organic and water content. The translucency and white appearance of enamel are attributed to Hydroxyapatite (HA), which constitutes the major part of the inorganic component of dental hard tissue. With the advent of nanotechnology, the application of Nanohydroxyapatite (nHA) has piqued interest in dentistry due to its excellent mechanical, physical, and chemical properties. Compared to HA, nHA is found to have superior properties such as increased solubility, high surface energy and better biocompatibility. This is due to the morphological and structural similarity of nanosized hydroxyapatite particles to tooth hydroxyapatite crystals. These nanoparticles have been incorporated into various dental formulations for different applications to ensure comprehensive oral healthcare. To prevent dental caries, several nHA based dentifrices, mouth rinsing solutions and remineralizing pastes have been developed. nHA-based materials, such as nanocomposites, nano impression materials, and nanoceramics, have proven to be very effective in restoring tooth deformities (decay, fracture, and tooth loss). The nHA coating on the surface of the dental implant helps it bind to the bone by forming a biomimetic coating. A recent innovative strategy involves using nHA to reduce dentinal hypersensitivity and to reconstruct periodontal bone defects. The purpose of the present review is to discuss the different applications of nHA in dentistry, especially in preventive and restorative dentistry, dental implantology, bleaching and dentine hypersensitivity management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.