Evidence map›Paper›PMID 37817436›Full record

ArticleBMB reports2024

Stomach clusterin as a gut-derived feeding regulator.

Cherl NamKoong, Bohye Kim, Ji Hee Yu, Byung Soo Youn, Hanbin Kim, Evonne Kim, So Young Gil, Gil Myoung Kang, Chan Hee Lee, Young-Bum Kim and 3 more

Erratum issuedOpen access · goldAbstract readNews
PubMed Full text at PMC
In one paragraph

Article in BMB reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Cherl NamKoongAppetite Regulation Laboratory, Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul 05505, Korea.
Bohye KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080; Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 03080, Korea.
Ji Hee YuDivision of Endocrinology and Metabolism, Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Byung Soo YounOsteoneurogen, Inc., Seoul 08501, Korea.
Hanbin KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.
Evonne KimDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.
So Young GilAppetite Regulation Laboratory, Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul 05505, Korea.
Gil Myoung KangAppetite Regulation Laboratory, Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul 05505, Korea.
Chan Hee LeeAppetite Regulation Laboratory, Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul 05505, Korea.
Young-Bum KimDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Kyeong-Han ParkDepartment of Anatomy and Cell Biology, Kangwon National University College of Medicine, Chuncheon 24341, Korea.
Min-Seon KimAppetite Regulation Laboratory, Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul 05505; Division of Endocrinology and Metabolism, Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Obin KwonDepartment of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080; Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul 03080, Korea.
Ulsan College · KRSeoul National University · KRBeth Israel Deaconess Medical Center · USKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The stomach has emerged as a crucial endocrine organ in the regulation of feeding since the discovery of ghrelin. Gut-derived hormones, such as ghrelin and cholecystokinin, can act through the vagus nerve. We previously reported the satiety effect of hypothalamic clusterin, but the impact of peripheral clusterin remains unknown. In this study, we administered clusterin intraperitoneally to mice and observed its ability to suppress fasting-driven food intake. Interestingly, we found its synergism with cholecystokinin and antagonism with ghrelin. These effects were accompanied by increased c-fos immunoreactivity in nucleus tractus solitarius, area postrema, and hypothalamic paraventricular nucleus. Notably, truncal vagotomy abolished this response. The stomach expressed clusterin at high levels among the organs, and gastric clusterin was detected in specific enteroendocrine cells and the submucosal plexus. Gastric clusterin expression decreased after fasting but recovered after 2 hours of refeeding. Furthermore, we confirmed that stomachspecific overexpression of clusterin reduced food intake after overnight fasting. These results suggest that gastric clusterin may function as a gut-derived peptide involved in the regulation of feeding through the gut-brain axis. [BMB Reports 2024; 57(3): 149-154].

Indexed as

EatingGhrelinAnimalsCholecystokininClusterinFeeding BehaviorMiceStomachCholecystokininClusterinGhrelin

Identifiers

PMID37817436
PMCPMC10979347
OpenAlexW4387516288

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.