Evidence map›Paper›PMID 37817212›Full record

ReviewStem cell research & therapy2023

Advances in stem cell therapy for peritoneal fibrosis: from mechanisms to therapeutics.

Weiyan Huang, Demeng Xia, Wendi Bi, Xueli Lai, Bing Yu, Wei Chen

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Weiyan Huang *Department of Nephrology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Demeng Xia *Department of Pharmacy, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wendi BiDepartment of Nephrology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Xueli LaiDepartment of Nephrology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Bing YuDepartment of Cell Biology, Center for Stem Cell and Medicine, Naval Medical University (Second Military Medical University), Shanghai, China. smmucellyu@163.com.ORCID 0000-0002-3421-8601
Wei ChenDepartment of Nephrology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China. wujiang02@163.com.
Second Military Medical University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

"234" Program from Changhai Hospital 2020YXK041Foundation strengthening program in technical field of China 2019-JCJQ-JJ-08National Natural Science Foundation of China 82173369Science and Technology Commission of Shanghai Municipality 21ZR1478700
6 · The paper itself

Abstract

Peritoneal fibrosis (PF) is a pathophysiological condition caused by a variety of pathogenic factors. The most important features of PF are mesothelial-mesenchymal transition and accumulation of activated (myo-)fibroblasts, which hinder effective treatment; thus, it is critical to identify other practical approaches. Recently, stem cell (SC) therapy has been indicated to be a potential strategy for this disease. Increasing evidence suggests that many kinds of SCs alleviate PF mainly by differentiating into mesothelial cells; secreting cytokines and extracellular vesicles; or modulating immune cells, particularly macrophages. However, there are relatively few articles summarizing research in this direction. In this review, we summarize the risk factors for PF and discuss the therapeutic roles of SCs from different sources. In addition, we outline effective approaches and potential mechanisms of SC therapy for PF. We hope that our review of articles in this area will provide further inspiration for research on the use of SCs in PF treatment.

Indexed as

Peritoneal FibrosisCell- and Tissue-Based TherapyEpithelial-Mesenchymal TransitionEpitheliumFibroblastsFibrosisHumansPeritoneumCell therapyMechanismMesothelial–mesenchymal transitionPeritoneal fibrosisStem cell

Identifiers

PMID37817212
PMCPMC10566108
OpenAlexW4387475192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.