Evidence map›Paper›PMID 37817210›Full record

ArticleJournal of ovarian research2023

Characterization of tumour microenvironment reprogramming reveals invasion in epithelial ovarian carcinoma.

Yuanfu Zhang, Shu Sun, Yue Qi, Yifan Dai, Yangyang Hao, Mengyu Xin, Rongji Xu, Hongyan Chen, Xiaoting Wu, Qian Liu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ovarian research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Cross-assay RNA modeling reveals cancer biomarkers.bioRxiv : the preprint server for biology · 2026
    Article
  3. The role of HMGA1 in genome stability: Implications in human cancer.Cellular and molecular life sciences : CMLS · 2026
    Review
  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yuanfu Zhang *Department of Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Shu Sun *Department Gynecology and Obstetrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.
Yue Qi *College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Yifan DaiCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Yangyang HaoCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Mengyu XinCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Rongji XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Hongyan ChenCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Xiaoting WuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Qian LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.
Congcong KongDepartment of Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Guangmei ZhangDepartment of Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China. guangmei_zhang@126.com.
Peng WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China. wpgqy@hrbmu.edu.cn.
Qiuyan GuoDepartment of Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin, 150081, China. guoqiuyan321@126.com.
Harbin Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CN

Funding

National Natural Science Foundation of China 32070622University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province UNPYSCT-2020173
6 · The paper itself

Abstract

backgroundPatients with epithelial ovarian carcinoma (EOC) are usually diagnosed at an advanced stage with tumour cell invasion. However, identifying the underlying molecular mechanisms and biomarkers of EOC proliferation and invasion remains challenging.

resultsHerein, we explored the relationship between tumour microenvironment (TME) reprogramming and tissue invasion based on single-cell RNA sequencing (scRNA-seq) datasets. Interestingly, hypoxia, oxidative phosphorylation (OXPHOS) and glycolysis, which have biologically active trajectories during epithelial mesenchymal transition (EMT), were positively correlated. Moreover, energy metabolism and anti-apoptotic activity were found to be critical contributors to intratumor heterogeneity. In addition, HMGA1, EGR1 and RUNX1 were found to be critical drivers of the EMT process in EOC. Experimental validation revealed that suppressing EGR1 expression inhibited tumour cell invasion, significantly upregulated the expression of E-cadherin and decreased the expression of N-cadherin. In cell components analysis, cancer-associated fibroblasts (CAFs) were found to significantly contribute to immune infiltration and tumour invasion, and the accumulation of CAFs was associated with poorer patient survival.

conclusionWe revealed the molecular mechanism and biomarkers of tumour invasion and TME reprogramming in EOC, which provides effective targets for the suppression of tumour invasion.

Indexed as

Ovarian NeoplasmsBiomarkersCarcinoma, Ovarian EpithelialCell Line, TumorEpithelial-Mesenchymal TransitionFemaleHumansTumor MicroenvironmentBiomarkersEpithelial ovarian carcinomaIntratumor heterogeneitySingle-cell RNA sequencingTissue invasionTumour microenvironment reprogramming

Identifiers

PMID37817210
PMCPMC10563280
OpenAlexW4387500920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.