Evidence map›Paper›PMID 37817164›Full record

ArticleBMC veterinary research2023

Polyautoimmunity manifest as inflammatory myopathy, uveitis, and progressive cutaneous depigmentation in a mixed breed dog: a case report.

Mary Ann Lee, Sean E Hulsebosch, Verena K Affolter, Jonathan D Dear, Marguerite F Knipe, David J Maggs, Bret A Moore, Catherine A Outerbridge, Sina Marsilio

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mary Ann LeeSchool of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Sean E HulseboschDepartment of Medicine and Epidemiology, University of California, Davis, 1 Garrod Drive, Davis, CA, 95616, USA.
Verena K AffolterDepartment of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA, USA.
Jonathan D DearDepartment of Medicine and Epidemiology, University of California, Davis, 1 Garrod Drive, Davis, CA, 95616, USA.
Marguerite F KnipeDepartment of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, USA.
David J MaggsDepartment of Surgical and Radiological Sciences, University of California, Davis, Davis, CA, USA.
Bret A MooreDepartment of Small Animal Clinical Sciences, University of Florida, Gainesville, FL, USA.
Catherine A OuterbridgeDepartment of Medicine and Epidemiology, University of California, Davis, 1 Garrod Drive, Davis, CA, 95616, USA.
Sina MarsilioDepartment of Medicine and Epidemiology, University of California, Davis, 1 Garrod Drive, Davis, CA, 95616, USA. smarsilio@ucdavis.edu.ORCID http://orcid.org/0000-0002-0693-0669
University of California, Davis · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolyautoimmunity is the expression of more than one autoimmune disease in a single patient. This report documents polyautoimmunity in a mixed breed dog with concurrent uveitis, cutaneous depigmentation, and inflammatory myopathy. CASE PRESENTATION: A 1-year-old male neutered mixed breed dog was presented for progressive generalized leukotrichia and leukoderma, bilateral panuveitis, and masticatory muscle atrophy. The latter progressed to myositis of lingual, pharyngeal, and masticatory muscles confirmed by biopsy. Temporalis muscle was completely replaced by adipose and fibrous tissue, and necrotic myofibers with extensive infiltration of mononuclear cells indicated active myositis of lingual muscle. Skin biopsies showed severe melanin clumping in epidermis, hair follicles, and hair shafts, and perifollicular pigmentary incontinence. Uveitis, depigmentation, and myositis affecting the masticatory, pharyngeal, and tongue muscles were diagnosed based on clinical, histological, and laboratory findings.

conclusionsTo the authors' knowledge, this is the first report of concurrent uveitis, progressive cutaneous depigmentation, and inflammatory myopathy in a dog.

Indexed as

Autoimmune DiseasesDog DiseasesMyositisUveitisUveomeningoencephalitic SyndromeAnimalsDogsMaleSkinGeneralized depigmentationInflammatory myopathyPolyautoimmunityUveodermatological syndromeVKH-like syndromeVogt-Koyanagi-Harada disease

Identifiers

PMID37817164
PMCPMC10563350
OpenAlexW4387499230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.