Evidence map›Paper›PMID 37817147›Full record

ArticleBMC psychiatry2023

Comparison between continued inpatient treatment versus day patient treatment after short inpatient care in early onset anorexia nervosa (COTIDEA trial): a study protocol for a non-inferiority randomised controlled trial.

A Ayrolles, A Bargiacchi, J Clarke, M Michel, F Baillin, V Trebossen, H Poncet Kalifa, S Guilmin-Crépon, R Delorme, N Godart and 1 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04479683 ("COTIDEA COmparison Between Continued Inpatient Treatment Versus Day Patient Treatment), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04479683 narecruitingnot on this map

"COTIDEA COmparison Between Continued Inpatient Treatment Versus Day Patient Treatment (Partial Hospitalization) After Short Inpatient Care in Early Onset Anorexia Nervosa: a Non-inferiority Trial A Non-inferiority Study"

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2021 to 2027Enrolled88ConditionsEarly Onset Anorexia NervosaArmsFTH then DH support, standard care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

A AyrollesChild and Adolescent Psychiatry Department, Reference Center for Rare Early-Onset Restrictive Eating Disorder, Robert Debré University Hospital, APHP, Paris, France. anael.ayrolles@aphp.fr.
A BargiacchiChild and Adolescent Psychiatry Department, Reference Center for Rare Early-Onset Restrictive Eating Disorder, Robert Debré University Hospital, APHP, Paris, France.
J ClarkeInstitute of Psychiatry and Neuroscience of Paris, INSERM U1266, Paris, France.
M MichelUniversité Paris Cité, Paris, France.
F BaillinChild and Adolescent Psychiatry Department, Reference Center for Rare Early-Onset Restrictive Eating Disorder, Robert Debré University Hospital, APHP, Paris, France.
V TrebossenChild and Adolescent Psychiatry Department, Reference Center for Rare Early-Onset Restrictive Eating Disorder, Robert Debré University Hospital, APHP, Paris, France.
H Poncet KalifaChild and Adolescent Psychiatry Department, Reference Center for Rare Early-Onset Restrictive Eating Disorder, Robert Debré University Hospital, APHP, Paris, France.
S Guilmin-CréponInserm, ECEVE, U1123, 10 Boulevard de Verdun, 75010, Paris, France.
R DelormeChild and Adolescent Psychiatry Department, Reference Center for Rare Early-Onset Restrictive Eating Disorder, Robert Debré University Hospital, APHP, Paris, France.
N GodartCESP, INSERM, UMR 1018, University Paris-Sud, UVSQ, University Paris-Saclay, Villejuif, France.
C StordeurChild and Adolescent Psychiatry Department, Reference Center for Rare Early-Onset Restrictive Eating Disorder, Robert Debré University Hospital, APHP, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn children with early-onset anorexia nervosa (first symptoms before 13 years old, EO-AN), experts recommend initial outpatient treatment but in-patient treatment (IP) is frequently indicated due to acute medical instability or for those who have not improved with outpatient treatment. This IP can target either a partial weight restauration or a total weight normalization (return to the previous BMI growth trajectory). There are no evidence in the literature on which is the better therapeutic option in EOAN. But as long length of stay induce social isolation, with elevated costs, we wonder if a stepped-care model of daypatient treatment (DP) after short IP stabilisation may be a treatment option as effective as full-time IP to target weight normalization. We designed a two-arm randomised controlled trial testing the non-inferiority of a stepped-care model of DP after short IP stabilisation versus full-time IP.

methodsEighty-eight children aged 8 to 13 years suffering from EOAN with initial severe undernutrition will be randomly allocated to either IP treatment as usual or a stepped care DP model both targeting weight normalization. Assessments will be conducted at inclusion, somatic stabilization, weight normalization, 6 months and 12 months post randomisation. The primary outcome will be BMI at 12 months post-randomisation. Secondaries outcomes will included clinical (tanner stage), biological (prealbumin, leptin, total ghrelin and IGF1) and radiological (bone mineralization and maturation) outcomes, eating symptomatology and psychiatric assessments, motivation to change, treatment acceptability and quality of life assessments, cost-utility and cost-effectiveness analyses. DISCUSSION: COTIDEA will provide rigorous evaluation of treatment alternative to full-time inpatient treatment to allow a reduction of social iatrogenic link to hospital length of stay and associated costs.

trial registrationTrial is registered on ClinicalTrials.gov (NCT04479683).

Indexed as

Anorexia NervosaAdolescentAmbulatory CareChildEquivalence Trials as TopicHospitalizationHumansInpatientsQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeCost-effectivenessDay-treatmentEarly-onset anorexia nervosa

Identifiers

PMID37817147
PMCPMC10563254

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.