Evidence map›Paper›PMID 37817008›Full record

ArticleProtein science : a publication of the Protein Society2023

14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices.

Olivia Petrvalska, Karolina Honzejkova, Nicola Koupilova, Petr Herman, Veronika Obsilova, Tomas Obsil

Open access · hybridAbstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Olivia PetrvalskaDepartment of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Karolina HonzejkovaDepartment of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Nicola KoupilovaDepartment of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic.
Petr HermanInstitute of Physics, Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic.
Veronika ObsilovaInstitute of Physiology of the Czech Academy of Sciences, Laboratory of Structural Biology of Signaling Proteins, Division BIOCEV, Vestec, Czech Republic.ORCID 0000-0003-4887-0323
Tomas ObsilDepartment of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Prague, Czech Republic.ORCID 0000-0003-4602-1272
Charles University · CZCzech Academy of Sciences · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ca

Indexed as

14-3-3 ProteinsCalcium-Calmodulin-Dependent Protein Kinase KinaseCatalytic DomainPhosphorylationScattering, Small AngleX-Ray Diffraction14-3-3 ProteinsCalcium-Calmodulin-Dependent Protein Kinase Kinase14-3-3 proteinscalcium/calmodulin-dependent protein kinaseCaMKKfluorescence spectroscopyhydrogen/deuterium exchange coupled to MSprotein-protein interactionSAXS

Identifiers

PMID37817008
PMCPMC10588359
OpenAlexW4387516085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.