Evidence map›Paper›PMID 37816837›Full record

ReviewCommunications medicine2023

The future landscape of large language models in medicine.

Jan Clusmann, Fiona R Kolbinger, Hannah Sophie Muti, Zunamys I Carrero, Jan-Niklas Eckardt, Narmin Ghaffari Laleh, Chiara Maria Lavinia Löffler, Sophie-Caroline Schwarzkopf, Michaela Unger, Gregory P Veldhuizen and 2 more

Registry-linked trialAbstract readReview
In one paragraph

Review in Communications medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07500428 (Construction of a Standardized Benchmark Evaluation System for Intelligent Breast Ultrasound Image Interpretation and Systematic Performance Assessment of Multimodal Artificial Intelligence Models Based on ACR BI-RADS v2025 Criteria), which is not on this map. Cited by 500 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
500citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07500428 recruitingnot on this mapstarted 2026, after this paper: background citation

Construction of a Standardized Benchmark Evaluation System for Intelligent Breast Ultrasound Image Interpretation and Systematic Performance Assessment of Multimodal Artificial Intelligence Models Based on ACR BI-RADS v2025 Criteria

TypeobservationalSponsorPeking Union Medical College HospitalRan2026 to 2027Enrolled1,380ConditionsBreast Neoplasms, Breast Diseases, UltrasonographyArmsMultimodal AI Model Diagnostic Evaluation
3 · Its place in the literature

Who cites it

500 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  16. A pragmatic risk-stratified framework for using large language models in intensive care medicine: A narrative review.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Review
  17. Review
  18. Artificial intelligence in clinical genetics: Current practice and attitudes among the clinical genetics workforce.Genetics in medicine : official journal of the American College of Medical Genetics · 2026
    Article
  19. Article
  20. Article

440 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jan Clusmann *Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0000-0003-2925-8438
Fiona R Kolbinger *Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0000-0003-2265-4809
Hannah Sophie Muti *Else Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.
Zunamys I CarreroElse Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0000-0001-8501-1566
Jan-Niklas EckardtElse Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.
Narmin Ghaffari LalehElse Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.
Chiara Maria Lavinia LöfflerElse Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.
Sophie-Caroline SchwarzkopfDepartment of Visceral, Thoracic and Vascular Surgery, University Hospital and Faculty of Medicine Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Michaela UngerElse Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.ORCID http://orcid.org/0000-0001-5811-0200
Gregory P VeldhuizenElse Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany.
Sophia J WagnerHelmholtz Munich-German Research Center for Environment and Health, Munich, Germany.
Jakob Nikolas KatherElse Kroener Fresenius Center for Digital Health, TUD Dresden University of Technology, Dresden, Germany. jakob-nikolas.kather@alumni.dkfz.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large language models (LLMs) are artificial intelligence (AI) tools specifically trained to process and generate text. LLMs attracted substantial public attention after OpenAI's ChatGPT was made publicly available in November 2022. LLMs can often answer questions, summarize, paraphrase and translate text on a level that is nearly indistinguishable from human capabilities. The possibility to actively interact with models like ChatGPT makes LLMs attractive tools in various fields, including medicine. While these models have the potential to democratize medical knowledge and facilitate access to healthcare, they could equally distribute misinformation and exacerbate scientific misconduct due to a lack of accountability and transparency. In this article, we provide a systematic and comprehensive overview of the potentials and limitations of LLMs in clinical practice, medical research and medical education.

Identifiers

PMID37816837
PMCPMC10564921

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.