Evidence map›Paper›PMID 37816827›Full record

ArticleScientific reports2023

CD73 deficiency does not aggravate angiotensin II-induced aortic inflammation in mice.

Timo Massold, Fady Ibrahim, Viola Niemann, Bodo Steckel, Katrin Becker, Jürgen Schrader, Johannes Stegbauer, Sebastian Temme, Maria Grandoch, Ulrich Flögel and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Timo Massold *Experimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Fady Ibrahim *Experimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Viola NiemannInstitute for Translational Pharmacology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Bodo SteckelDepartment of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Katrin BeckerDepartment of Cardiology, Pulmonology, and Angiology, University Hospital Düsseldorf, Düsseldorf, Germany.
Jürgen SchraderDepartment of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Johannes StegbauerDepartment of Nephrology, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225, Düsseldorf, Germany.
Sebastian TemmeDepartment of Anesthesiology, University Hospital Düsseldorf, Düsseldorf, Germany.
Maria GrandochInstitute for Translational Pharmacology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Ulrich FlögelExperimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. floegel@uni-duesseldorf.de.
Pascal BouvainExperimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. pascal.bouvain@uni-duesseldorf.de.
Heinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular inflammation plays a key role in the development of aortic diseases. A potential novel target for treatment might be CD73, an ecto-5'-nucleotidase that generates anti-inflammatory adenosine in the extracellular space. Here, we investigated whether a lack of CD73 results in enhanced aortic inflammation. To this end, angiotensin II was infused into wildtype and CD73

Indexed as

5'-NucleotidaseAngiotensin IIAdenosineAnimalsFemaleGPI-Linked ProteinsInflammationMaleMiceMice, Knockout5'-NucleotidaseAdenosineAngiotensin IIGPI-Linked ProteinsNt5e protein, mouse

Identifiers

PMID37816827
PMCPMC10564884
OpenAlexW4387494345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.