Evidence map›Paper›PMID 37816802›Full record

ArticleScientific reports2023

A retrospective comparative study of anesthesia with remimazolam and remifentanil versus dexmedetomidine and remifentanil for transcatheter aortic valve replacement.

Atsuhiro Kitaura, Shota Tsukimoto, Hiroatsu Sakamoto, Shinichi Hamasaki, Shinichi Nakao, Yasufumi Nakajima

Open access · goldAbstract readComparative Study
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

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  8. Remimazolam in anesthesia and sedation: A narrative review.Journal of anesthesia and translational medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Atsuhiro KitauraDepartment of Anesthesiology, Kindai University Faculty of Medicine, 377-2 Ono-Higashi, Osakasayama, Osaka, Japan. kitaura@med.kindai.ac.jp.
Shota TsukimotoDepartment of Anesthesiology, Kindai University Faculty of Medicine, 377-2 Ono-Higashi, Osakasayama, Osaka, Japan.
Hiroatsu SakamotoDepartment of Anesthesiology, Kindai University Faculty of Medicine, 377-2 Ono-Higashi, Osakasayama, Osaka, Japan.
Shinichi HamasakiDepartment of Anesthesiology, Kindai University Faculty of Medicine, 377-2 Ono-Higashi, Osakasayama, Osaka, Japan.
Shinichi NakaoDepartment of Anesthesiology, Kindai University Faculty of Medicine, 377-2 Ono-Higashi, Osakasayama, Osaka, Japan.
Yasufumi NakajimaDepartment of Anesthesiology, Kindai University Faculty of Medicine, 377-2 Ono-Higashi, Osakasayama, Osaka, Japan.
Kindai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Remimazolam, an ultrashort-acting benzodiazepine, allows for rapid and reliable arousal. Rapid awakening using remimazolam may be beneficial in transcatheter aortic valve replacement (TAVR), as it allows rapid detection of neurologic deficits. The purpose of this study was to compare arousal time and outcomes between monitored anesthesia care (MAC) with remimazolam and remifentanil and conventional MAC with dexmedetomidine, propofol, and remifentanil. This study was a single center retrospective study. All TAVR cases performed under MAC (MAC-TAVR) at our institution between 2019 and 2021 were included. Patients were classified by anesthesia method into remimazolam and dexmedetomidine groups. Among 258 MAC-TAVR patients, 253 were enrolled. After propensity score matching, 76 patients were assigned to each group. The time from end of drug-administration to arousal [20.0 (16.0, 24.0) min vs. 38.5 (30.0, 56.3) min, p < 0.0001] and the time from attempted-arousal to arousal [1.0 (1.0, 1.0) min vs. 12.5 (3.0, 26.8) min, p < 0.0001] were significantly shorter in the remimazolam group. There was no significant difference in the length of ICU stay [2.0 (2.0, 2.0) days vs. 2.0 (2.0, 2.0) days, p = 0.157] and postoperative hospital stay [6.0 (4.0, 9.0) days vs. 5.0 (4.0, 8.0) days, p = 0.262].Trial registration: Clinical trial number: R03-123, Registry URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000051635 Registration number: UMIN000045195, Principal investigator's name: Atsuhiro Kitaura, Date of registration: 20 August 2021.

Indexed as

Aortic Valve StenosisDexmedetomidineTranscatheter Aortic Valve ReplacementAnesthesia, GeneralBenzodiazepinesHumansRemifentanilRetrospective StudiesTreatment OutcomeBenzodiazepinesDexmedetomidineRemifentanilremimazolam

Identifiers

PMID37816802
PMCPMC10564871
OpenAlexW4387498309

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.