Evidence map›Paper›PMID 37816736›Full record

ArticleNature communications2023

Unaltered hepatic wound healing response in male rats with ancestral liver injury.

Johanna Beil, Juliane Perner, Lena Pfaller, Marie-Apolline Gérard, Alessandro Piaia, Arno Doelemeyer, Adi Wasserkrug Naor, Lori Martin, Aline Piequet, Valérie Dubost and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Johanna Beil *Novartis, Biomedical Research, Basel, Switzerland.
Juliane Perner *Novartis, Biomedical Research, Basel, Switzerland.
Lena Pfaller *Novartis, Biomedical Research, Basel, Switzerland.
Marie-Apolline GérardNovartis, Biomedical Research, Basel, Switzerland.
Alessandro PiaiaNovartis, Biomedical Research, Basel, Switzerland.
Arno DoelemeyerNovartis, Biomedical Research, Basel, Switzerland.ORCID http://orcid.org/0000-0003-1471-6459
Adi Wasserkrug NaorNovartis, Biomedical Research, East-Hanover, NJ, USA.
Lori MartinNovartis, Biomedical Research, East-Hanover, NJ, USA.
Aline PiequetNovartis, Biomedical Research, Basel, Switzerland.
Valérie DubostNovartis, Biomedical Research, Basel, Switzerland.
Salah-Dine ChiboutNovartis, Biomedical Research, Basel, Switzerland.
Jonathan MoggsNovartis, Biomedical Research, Basel, Switzerland.
Rémi TerranovaNovartis, Biomedical Research, Basel, Switzerland. remi.terranova@novartis.com.ORCID http://orcid.org/0000-0002-2119-679X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The possibility that ancestral environmental exposure could result in adaptive inherited effects in mammals has been long debated. Numerous rodent models of transgenerational responses to various environmental factors have been published but due to technical, operational and resource burden, most still await independent confirmation. A previous study reported multigenerational epigenetic adaptation of the hepatic wound healing response upon exposure to the hepatotoxicant carbon tetrachloride (CCl

Indexed as

DNA MethylationEpigenesis, GeneticLiverWound HealingAnimalsCarbon TetrachlorideMaleRatsCarbon Tetrachloride

Identifiers

PMID37816736
PMCPMC10564731

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.