Evidence map›Paper›PMID 37816735›Full record

ArticleCell death & disease2023

Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush.

Syed A H Zaidi, Zhimin Xu, Tahira Lemtalsi, Porsche Sandow, Sruthi Athota, Fang Liu, Stephen Haigh, Yuqing Huo, S Priya Narayanan, David J R Fulton and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Syed A H Zaidi *Vascular Biology Center, Augusta University, Augusta, GA, 30912, USA. syezaidi@augusta.edu.ORCID 0000-0002-9177-0881
Zhimin Xu *Vascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Tahira LemtalsiVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Porsche SandowJames and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, 30912, USA.
Sruthi AthotaVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Fang LiuJames and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, 30912, USA.
Stephen HaighVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Yuqing HuoVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
S Priya NarayananVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
David J R FultonVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Modesto A RojasVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.
Abdelrahman Y FoudaVascular Biology Center, Augusta University, Augusta, GA, 30912, USA.ORCID 0000-0003-3042-9425
Robert W CaldwellJames and Jean Culver Vision Discovery Institute, Augusta University, Augusta, GA, 30912, USA.
Ruth B CaldwellVascular Biology Center, Augusta University, Augusta, GA, 30912, USA. rcaldwel@augusta.edu.ORCID 0000-0003-0168-0354
Augusta University · USAugusta University Health · USUniversity of Georgia · US

Funding

Cellular Mechanisms of Retinopathy: Role of ArginaseR01EY011766 · NEI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI CALDWELL, ROBERT WILLIAM, CALDWELL, RUTH B · 1998 to 2021
$6.7M
Module 3: Gene Expression/ProteomicsP30EY031631 · NEI · AUGUSTA UNIVERSITY · PI Xingjun Fan · 2020 to 2026
$3.6M
Myeloid glycolysis in pathological ocular angiogenesisR01EY030500 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2019 to 2023
$2.6M
Adenosine receptor 2A in subretinal fibrosisR01EY033737 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Ruth B Caldwell, YUQING HUO · 2022 to 2026
$2.1M
"Myeloid PFKFB3 in subretinal fibrosis"R01EY033369 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, HUO, YUQING · 2022 to 2025
$1.6M
Role of Arginase 1 in Retinal Ischemia-Reperfusion InjuryR00EY029373 · NEI · UNIV OF ARKANSAS FOR MED SCIS · PI FOUDA, ABDELRAHMAN · 2022 to 2024
$854k
Role of ACAT1 in Pathological Retinal NeovascularizationR21EY032265 · NEI · AUGUSTA UNIVERSITY · PI CALDWELL, RUTH B, ROJAS, MODESTO ANTONIO · 2021 to 2022
$418k
NEI NIH HHS P30 EY031631NEI NIH HHS R00 EY029373NEI NIH HHS R01 EY011766NEI NIH HHS R01 EY030500NEI NIH HHS R01 EY033369NEI NIH HHS R01 EY033737NEI NIH HHS R21 EY032265
6 · The paper itself

Abstract

We previously found that global deletion of the mitochondrial enzyme arginase 2 (A2) limits optic nerve crush (ONC)-induced neuronal death. Herein, we examined the cell-specific role of A2 in this pathology by studies using wild type (WT), neuronal-specific calbindin 2 A2 KO (Calb2

Indexed as

ArginaseOptic Nerve InjuriesAnimalsApoptosisCalbindin 2Disease Models, AnimalEndothelial CellsGlutamatesMiceNerve CrushOptic NerveArg2 protein, mouseArginaseCalb2 protein, mouseCalbindin 2Glutamates

Identifiers

PMID37816735
PMCPMC10564748
OpenAlexW4387500537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.