Evidence map›Paper›PMID 37816685›Full record

ArticleBrain pathology (Zurich, Switzerland)2024

Poly-GA immunohistochemistry is a reliable tool for detecting C9orf72 hexanucleotide repeat expansions.

Jordan Carroll, Heather McCann, Glenda M Halliday, John B Kwok, Carol Dobson-Stone, Claire E Shepherd

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jordan CarrollNeuroscience Research Australia, Randwick, New South Wales, Australia.
Heather McCannNeuroscience Research Australia, Randwick, New South Wales, Australia.
Glenda M HallidayFaculty of Medicine and Health, School of Medical Sciences, University of Sydney Brain and Mind Centre, Camperdown, New South Wales, Australia.
John B KwokFaculty of Medicine and Health, School of Medical Sciences, University of Sydney Brain and Mind Centre, Camperdown, New South Wales, Australia.
Carol Dobson-StoneFaculty of Medicine and Health, School of Medical Sciences, University of Sydney Brain and Mind Centre, Camperdown, New South Wales, Australia.
Claire E ShepherdNeuroscience Research Australia, Randwick, New South Wales, Australia.ORCID 0000-0003-0990-7592
The University of Sydney · AUNeuroscience Research Australia · AUUNSW Sydney · AU

Funding

National Health and Medical Research Council 1138223National Health and Medical Research Council 1163249National Health and Medical Research Council 1176607
6 · The paper itself

Abstract

Poly-GA immunohistochemistry (A) on formalin fixed paraffin embedded cerebellum sections shows a similar distribution to p62 antibody (B) and reliably identifies neuronal cytoplasmic inclusions and neurites in cases with known C9orf72 repeat expansion. This is useful in the research setting where genetic testing has not been performed in life or suitable tissue is not avilable post-mortem.

Indexed as

C9orf72 ProteinDNA Repeat ExpansionImmunohistochemistryAgedAmyotrophic Lateral SclerosisCerebellumFemaleFrontotemporal DementiaHumansInclusion BodiesMaleMiddle AgedNeuronsProteinsC9orf72 ProteinC9orf72 protein, humanProteinsC9orf72poly‐GATDP‐43

Identifiers

PMID37816685
PMCPMC11328337
OpenAlexW4387474212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.