Evidence map›Paper›PMID 37816646›Full record

ArticleNeurology2023

Large Language Models in Neurology Research and Future Practice.

Michael F Romano, Ludy C Shih, Ioannis C Paschalidis, Rhoda Au, Vijaya B Kolachalama

Open access · hybridAbstract read
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Observational
  12. Fine-Tuning Large Language Models for Specialized Use Cases.Mayo Clinic proceedings. Digital health · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Large language models for neurology: a mini review.Frontiers in digital health · 2025
    Review
  17. Article
  18. The Digitized Memory Clinic.Nature reviews. Neurology · 2024
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael F RomanoFrom the Department of Medicine (M.F.R., R.A., V.B.K.), Boston University Chobanian & Avedisian School of Medicine, MA; Department of Radiology and Biomedical Imaging (M.F.R.), University of California, San Francisco; Department of Neurology (L.C.S., R.A.), Boston University Chobanian & Avedisian School of Medicine; Department of Electrical and Computer Engineering (I.C.P.), Division of Systems Engineering, and Department of Biomedical Engineering; Faculty of Computing and Data Sciences (I.C.P., V.B.K.), Boston University; Department of Anatomy and Neurobiology (R.A.); The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine; Department of Epidemiology, Boston University School of Public Health; Boston University Alzheimer's Disease Research Center (R.A.); and Department of Computer Science (V.B.K.), Boston University, MA.ORCID 0000-0002-7022-9252
Ludy C ShihFrom the Department of Medicine (M.F.R., R.A., V.B.K.), Boston University Chobanian & Avedisian School of Medicine, MA; Department of Radiology and Biomedical Imaging (M.F.R.), University of California, San Francisco; Department of Neurology (L.C.S., R.A.), Boston University Chobanian & Avedisian School of Medicine; Department of Electrical and Computer Engineering (I.C.P.), Division of Systems Engineering, and Department of Biomedical Engineering; Faculty of Computing and Data Sciences (I.C.P., V.B.K.), Boston University; Department of Anatomy and Neurobiology (R.A.); The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine; Department of Epidemiology, Boston University School of Public Health; Boston University Alzheimer's Disease Research Center (R.A.); and Department of Computer Science (V.B.K.), Boston University, MA.ORCID 0000-0002-6590-8365
Ioannis C PaschalidisFrom the Department of Medicine (M.F.R., R.A., V.B.K.), Boston University Chobanian & Avedisian School of Medicine, MA; Department of Radiology and Biomedical Imaging (M.F.R.), University of California, San Francisco; Department of Neurology (L.C.S., R.A.), Boston University Chobanian & Avedisian School of Medicine; Department of Electrical and Computer Engineering (I.C.P.), Division of Systems Engineering, and Department of Biomedical Engineering; Faculty of Computing and Data Sciences (I.C.P., V.B.K.), Boston University; Department of Anatomy and Neurobiology (R.A.); The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine; Department of Epidemiology, Boston University School of Public Health; Boston University Alzheimer's Disease Research Center (R.A.); and Department of Computer Science (V.B.K.), Boston University, MA.ORCID 0000-0002-3343-2913
Rhoda AuFrom the Department of Medicine (M.F.R., R.A., V.B.K.), Boston University Chobanian & Avedisian School of Medicine, MA; Department of Radiology and Biomedical Imaging (M.F.R.), University of California, San Francisco; Department of Neurology (L.C.S., R.A.), Boston University Chobanian & Avedisian School of Medicine; Department of Electrical and Computer Engineering (I.C.P.), Division of Systems Engineering, and Department of Biomedical Engineering; Faculty of Computing and Data Sciences (I.C.P., V.B.K.), Boston University; Department of Anatomy and Neurobiology (R.A.); The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine; Department of Epidemiology, Boston University School of Public Health; Boston University Alzheimer's Disease Research Center (R.A.); and Department of Computer Science (V.B.K.), Boston University, MA.ORCID 0000-0001-7742-4491
Vijaya B KolachalamaFrom the Department of Medicine (M.F.R., R.A., V.B.K.), Boston University Chobanian & Avedisian School of Medicine, MA; Department of Radiology and Biomedical Imaging (M.F.R.), University of California, San Francisco; Department of Neurology (L.C.S., R.A.), Boston University Chobanian & Avedisian School of Medicine; Department of Electrical and Computer Engineering (I.C.P.), Division of Systems Engineering, and Department of Biomedical Engineering; Faculty of Computing and Data Sciences (I.C.P., V.B.K.), Boston University; Department of Anatomy and Neurobiology (R.A.); The Framingham Heart Study, Boston University Chobanian & Avedisian School of Medicine; Department of Epidemiology, Boston University School of Public Health; Boston University Alzheimer's Disease Research Center (R.A.); and Department of Computer Science (V.B.K.), Boston University, MA. vkola@bu.edu.ORCID 0000-0002-5312-8644
Boston University · US

Funding

TBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Lindsay A. Farrer · 2020 to 2026
$42.4M
Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
Precision Brain Health Monitoring for Alzheimer's Disease Risk Detection in the Framingham Study: Black & AA Recruitment SupplementRF1AG072654 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, GOLDSTEIN, LEE E. · 2021 to 2023
$2.4M
Mechanisms of drug-coated balloon therapyR01HL159620 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOLACHALAMA, VIJAYA B. · 2021 to 2024
$2.1M
Cognitive Heterogeneity in those with high Alzheimer's Disease RiskRF1AG062109 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA · 2020 to 2021
$1.8M
PRISTINE: Pre-cancer histology identification of Endobronchial biopsies using deep learningR21CA253498 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BEANE, JENNIFER ELLEN, KOLACHALAMA, VIJAYA B. · 2020 to 2020
$424k
Smartphone image analysis for real time adequacy assessment during kidney biopsyR43DK134273 · NIDDK · NEPHROPATHOLOGY ASSOCIATES · PI KOLACHALAMA, VIJAYA B., SHARMA, SHREE GOPAL · 2022 to 2022
$252k
NCI NIH HHS R21 CA253498NHLBI NIH HHS R01 HL159620NIA NIH HHS P30 AG013846NIA NIH HHS RF1 AG062109NIA NIH HHS RF1 AG072654NIA NIH HHS U19 AG068753NIDDK NIH HHS R43 DK134273
6 · The paper itself

Abstract

Recent advancements in generative artificial intelligence, particularly using large language models (LLMs), are gaining increased public attention. We provide a perspective on the potential of LLMs to analyze enormous amounts of data from medical records and gain insights on specific topics in neurology. In addition, we explore use cases for LLMs, such as early diagnosis, supporting patient and caregivers, and acting as an assistant for clinicians. We point to the potential ethical and technical challenges raised by LLMs, such as concerns about privacy and data security, potential biases in the data for model training, and the need for careful validation of results. Researchers must consider these challenges and take steps to address them to ensure that their work is conducted in a safe and responsible manner. Despite these challenges, LLMs offer promising opportunities for improving care and treatment of various neurologic disorders

Indexed as

Artificial IntelligenceNeurologyHumansLanguageMedical RecordsResearch Personnel

Identifiers

PMID37816646
PMCPMC10752640
OpenAlexW4387485634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.