ArticleNeurology2023
Quality of Life in Patients With Confirmed and Suspected Spinal CSF Leaks.
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Patient-reported outcomes after surgical treatment of spontaneous intracranial hypotension: a cross-sectional study.Acta neurologica Belgica · 2026Article
- Spontaneous spinal CSF leaks: a rare variant exome sequencing study and functional analysis.The Lancet. Neurology · 2026Article
- "Getting to diagnosis was an absolute nightmare": survey insights about the lived experience of spinal CSF leak in Australia and Aotearoa New Zealand.Journal of neurology · 2026Article
- Early brain MRI changes following transvenous embolization of cerebrospinal fluid-venous fistulas in spontaneous intracranial hypotension.Journal of neurointerventional surgery · 2026Article
- The impact of CSF venous fistula embolization on patient's quality of life, a longitudinal clinical-radiological exploration.The journal of headache and pain · 2025Article
- Hypersensitivity Reactions to Fibrin Glue during Epidural Blood Patching.AJNR. American journal of neuroradiology · 2025Article
- Assessing the effects of spontaneous intracranial hypotension on quality of life, work ability and disability.Wiener klinische Wochenschrift · 2025Article
- Microsurgical Repair of Ventral Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension: Efficacy and Safety of Patch-Sealing Versus Suturing.Operative neurosurgery (Hagerstown, Md.) · 2025Article
- Myelographic Techniques for the Localization of CSF-Venous Fistulas: Updates in 2024.AJNR. American journal of neuroradiology · 2024Review
- Corrections to Received Date Information.Neurology · 2024Article
- Perspectives from the Inaugural "Spinal CSF Leak: Bridging the Gap" Conference: A Convergence of Clinical and Patient Expertise.AJNR. American journal of neuroradiology · 2024Article
- Diagnosis and Treatment of Spontaneous Intracranial Hypotension: Role of Epidural Blood Patching.Neurology. Clinical practice · 2024Review
- Optic Nerve Sheath MR Imaging Measurements in Patients with Orthostatic Headaches and Normal Findings on Conventional Imaging Predict the Presence of an Underlying CSF-Venous Fistula.AJNR. American journal of neuroradiology · 2024Article
- Health-related quality of life, work ability and disability among individuals with persistent post-dural puncture headache.The journal of headache and pain · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesSpontaneous intracranial hypotension (SIH) is a debilitating condition typically producing orthostatic headache limiting upright time. SIH is often difficult to diagnose and treat, negatively affecting quality of life (QoL) in patients with the disorder. We studied QoL in patients with confirmed and suspected SIH using standardized instruments, including suicidality.
methodsWe performed a cross-sectional survey of adult patients with confirmed and clinically suspected SIH evaluated in our Headache and Facial Pain Program from 2016 to 2022. Using an online data collection tool (REDCap V 11.2.2), participants completed validated questionnaires assessing general well-being (SF-36), depression (PHQ-9), generalized anxiety disorder-7 (GAD-7), spiritual well-being during chronic illness therapy (FACIT-Sp-12), and headache impact (HIT-6). Subsequently, we interviewed willing participants to administer the Columbia-Suicide Severity Rating Scale (C-SSRS) assessing suicidal behavior and ideation.
resultsA total of 234 patients met inclusion criteria and were invited to participate in the study, and 95 patients (59 confirmed and 36 clinically suspected) completed the questionnaires. The average age of the cohort was 51.1 years (SD: 15.5), predominantly female (69.5%), White (91.6%), and married (69.5%). Three-quarters (74.5%) scored within the most severe headache category (HIT-6). SF-36 scores were significantly inferior ( DISCUSSION: Based on our single-center cohort, SIH is associated with severe headache pain and high rates of depression, anxiety, and disability, affecting basic activities of daily living. Individuals with confirmed and suspected spinal CSF leaks scored similarly on these measures including suicidality. Outcomes were comparable with the general population after successful treatment or spontaneous remission. Improved identification and treatment of SIH are imperative to improve patients' QoL.
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