Evidence map›Paper›PMID 37816574›Full record

ArticleBMJ case reports2023

Isolated ACTH deficiency: an uncommon cause of hyperferritinaemia.

Atsushi Isoda, Akio Saito, Morio Matsumoto, Morio Sawamura

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 73% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Atsushi IsodaDepartment of Hematology, Iryo Hojin Hoshi Iin, Maebashi, Japan hoshiclinic01@gmail.com.ORCID http://orcid.org/0000-0002-3080-2341
Akio SaitoDepartment of Hematology, NHO Shibukawa Medical Center, Shibukawa, Japan.
Morio MatsumotoDepartment of Hematology, NHO Shibukawa Medical Center, Shibukawa, Japan.
Morio SawamuraDepartment of Hematology, NHO Shibukawa Medical Center, Shibukawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isolated adrenocorticotropic hormone deficiency (IAD) is a rare disorder but not a known cause of hyperferritinaemia. We here report a man with IAD who presented with mild anaemia and unexpected hyperferritinaemia (serum ferritin, 1796 µg/L). He had high serum hepcidin and relatively low erythropoietin levels for his anaemia, with hepcidin and ferritin levels reducing with hydrocortisone supplementation. We speculate that low glucocorticoid levels might suppress erythropoiesis and anti-inflammatory activity, resulting in a higher hepcidin level and hyperferritinaemia. The possibility of adrenal insufficiency including IAD should be considered as a differential diagnosis in patients with unexplained hyperferritinaemia.

Indexed as

AnemiaHepcidinsAdrenocorticotropic HormoneEndocrine System DiseasesFerritinsGenetic Diseases, InbornHumansHydrocortisoneHypoglycemiaMaleAdrenocorticotropic HormoneFerritinsHepcidinsHydrocortisoneAdrenal disordersHaematology (incl blood transfusion)Pituitary disorders

Identifiers

PMID37816574
PMCPMC10565305
OpenAlexW4387476154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.