ArticlePLoS genetics2023
Demographically explicit scans for barriers to gene flow using gIMble.
Article in PLoS genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- A standardised framework for classifying estimates of reproductive isolation.Evolution letters · 2026Article
- Adaptive introgression between two Drosophila species enhances heat tolerance despite barriers to gene flow.PLoS biology · 2026Article
- Repeated cases of allopatric divergence and secondary contact in cattail (Typha) speciation.Heredity · 2026Article
- Ancient inversion polymorphisms are locally adaptive in a widespread butterfly species.Science advances · 2026Article
- Common Chiffchaffs (Phylloscopus collybita) Diverge in a Genomic Region Associated With Migration Differences in Willow Warblers (Phylloscopus trochilus).Molecular ecology · 2026Article
- Introgression and Divergence in a Young Species Group.Molecular ecology · 2026Article
- Examining the Role of a Chromosomal Inversion in Accumulating Adaptive and Barrier Loci in a Cold-adapted Insect Species.Genome biology and evolution · 2026Article
- Genomic incompatibilities are persistent barriers when speciation happens with gene flow in Formica ants.Molecular biology and evolution · 2026Article
- Genomic analyses inEvolution letters · 2026Article
- Genomic insights into chromosomal fusion and its evolutionary implications for zokors.Molecular biology and evolution · 2026Article
- Review
- Do syngameons exist in tropical trees? Challenges to determine their existence and estimate their frequency.Biology letters · 2025Review
- Genomic regions of current low hybridisation mark long-term barriers to gene flow in scarce swallowtail butterflies.PLoS genetics · 2025Article
- High-recombining genomic regions affect demography inference based on ancestral recombination graphs.Genetics · 2025Article
- Incomplete recombination suppression fuels extensive haplotype diversity in a butterfly colour pattern supergene.PLoS biology · 2025Article
- Advances and challenges in understanding evolution through genome comparison: meeting report of the European Molecular Biology Organization (EMBO) lecture course "Evolutionary and Comparative Genomics".Bioinformatics advances · 2025Article
- Do chromosome rearrangements fix by genetic drift or natural selection? Insights from Brenthis butterflies.Molecular ecology · 2024Article
- Testing the genomic overlap between intraspecific mating traits and interspecific mating barriers.Evolution letters · 2024Article
- The genetic architecture of polygenic local adaptation and its role in shaping barriers to gene flow.Genetics · 2024Article
- Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying regions of the genome that act as barriers to gene flow between recently diverged taxa has remained challenging given the many evolutionary forces that generate variation in genetic diversity and divergence along the genome, and the stochastic nature of this variation. Progress has been impeded by a conceptual and methodological divide between analyses that infer the demographic history of speciation and genome scans aimed at identifying locally maladaptive alleles i.e. genomic barriers to gene flow. Here we implement genomewide IM blockwise likelihood estimation (gIMble), a composite likelihood approach for the quantification of barriers, that bridges this divide. This analytic framework captures background selection and selection against barriers in a model of isolation with migration (IM) as heterogeneity in effective population size (Ne) and effective migration rate (me), respectively. Variation in both effective demographic parameters is estimated in sliding windows via pre-computed likelihood grids. gIMble includes modules for pre-processing/filtering of genomic data and performing parametric bootstraps using coalescent simulations. To demonstrate the new approach, we analyse data from a well-studied pair of sister species of tropical butterflies with a known history of post-divergence gene flow: Heliconius melpomene and H. cydno. Our analyses uncover both large-effect barrier loci (including well-known wing-pattern genes) and a genome-wide signal of a polygenic barrier architecture.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.