Evidence map›Paper›PMID 37816059›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Pairwise biosynthesis of ion channels stabilizes excitability and mitigates arrhythmias.

Margaret B Jameson, Erick B Ríos-Pérez, Fang Liu, Catherine A Eichel, Gail A Robertson

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Margaret B JamesonDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0003-1225-9194
Erick B Ríos-PérezDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0002-2246-9112
Fang LiuDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.
Catherine A EichelDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.
Gail A RobertsonDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0003-4694-5790
University of Wisconsin–Madison · US

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
Translational Control of Cardiac ExcitabilityR01HL131403 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Gail A Robertson · 2016 to 2026
$6.0M
Allosteric Regulation of KCNH ChannelsR01NS081320 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERTSON, GAIL A · 2012 to 2022
$3.4M
NHLBI NIH HHS R01 HL131403NHLBI NIH HHS T32 HL007936NIGMS NIH HHS T32 GM008688NINDS NIH HHS R01 NS081320
6 · The paper itself

Abstract

Coordinated expression of ion channels is crucial for cardiac rhythms, neural signaling, and cell cycle progression. Perturbation of this balance results in many disorders including cardiac arrhythmias. Prior work revealed association of mRNAs encoding cardiac Na

Indexed as

Arrhythmias, CardiacKCNQ1 Potassium ChannelERG1 Potassium ChannelHumansIn Situ Hybridization, FluorescenceNAV1.5 Voltage-Gated Sodium ChannelRNA, MessengerRNA, Small InterferingERG1 Potassium ChannelKCNQ1 Potassium ChannelNAV1.5 Voltage-Gated Sodium ChannelRNA, MessengerRNA, Small InterferingcotranslationalexcitabilitymRNA associationPLAsmFISH

Identifiers

PMID37816059
PMCPMC10589643
OpenAlexW4387504019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.