Evidence map›Paper›PMID 37816050›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Downregulation of apoptotic repressor

Peng Yu, Shuai Song, Xiaokai Zhang, Shujun Cui, Gang Wei, Zihang Huang, Linqi Zeng, Ting Ni, Aijun Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Peng Yu *State Key Laboratory of Genetic Engineering, Human Phenome Institute, Department of Anthropology and Human Genetics, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0000-0002-5877-9761
Shuai Song *Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Xiaokai Zhang *Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0003-2878-2385
Shujun CuiState Key Laboratory of Genetic Engineering, Human Phenome Institute, Department of Anthropology and Human Genetics, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Gang WeiState Key Laboratory of Genetic Engineering, Human Phenome Institute, Department of Anthropology and Human Genetics, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.
Zihang HuangDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Linqi ZengDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Ting NiState Key Laboratory of Genetic Engineering, Human Phenome Institute, Department of Anthropology and Human Genetics, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0000-0001-7007-1072
Aijun SunState Key Laboratory of Genetic Engineering, Human Phenome Institute, Department of Anthropology and Human Genetics, School of Life Sciences and Zhongshan Hospital, Fudan University, Shanghai 200438, China.ORCID 0000-0003-1488-0937
Sun Yat-sen University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) is a leading cause of heart failure (HF), associated with morbidity and mortality worldwide. As an essential part of gene expression regulation, the role of alternative polyadenylation (APA) in post-MI HF remains elusive. Here, we revealed a global, APA-mediated, 3' untranslated region (3' UTR)-lengthening pattern in both human and murine post-MI HF samples. Furthermore, the 3' UTR of apoptotic repressor gene,

Indexed as

Heart InjuriesMicroRNAsMyocardial Infarction3' Untranslated RegionsAdaptor Proteins, Signal TransducingAnimalsApoptosisApoptosis Regulatory ProteinsDown-RegulationHumansMembrane ProteinsMiceMyocytes, CardiacPoly(A)-Binding Protein I3' Untranslated RegionsAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsAVEN protein, humanAven protein, mouseMembrane ProteinsMicroRNAsPABPN1 protein, humanPoly(A)-Binding Protein Ialternative polyadenylationapoptosisAVENmyocardial infarction

Identifiers

PMID37816050
PMCPMC10589712
OpenAlexW4387492391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.