Evidence map›Paper›PMID 37815894›Full record

ArticleAging2023

TTK is a potential regulator of tumor progression correlated with dedifferentiation and immune cell infiltration in papillary thyroid cancer.

Jun-Jie Ma, Cheng Xiang, Jian-Wei Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jun-Jie MaDepartment of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China.
Cheng XiangDepartment of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China.
Jian-Wei WangThe Colorectal Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang, China.
Second Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role and clinical significance of threonine tyrosine kinase (TTK) in papillary thyroid cancer (PTC).

methodsTTK expression in PTC and normal groups were compared using TCGA data and

resultsTTK upregulation was observed in PTC, and its elevated level was significantly related to an unfavorable prognosis (

conclusionTTK serves as a potential biomarker for tumorigenesis and prognosis in PTC, especially for those that may differentiate into more aggressive thyroid cancers.

Indexed as

MicroRNAsThyroid NeoplasmsCell Cycle ProteinsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansProtein Serine-Threonine KinasesProtein-Tyrosine KinasesThyroid Cancer, PapillaryCell Cycle ProteinsMicroRNAsMIRN582 microRNA, humanProtein Serine-Threonine KinasesProtein-Tyrosine KinasesTTK protein, humanbiomarkerpapillary thyroid cancerprognosisTTKtumorigenesis

Identifiers

PMID37815894
PMCPMC10599754
OpenAlexW4387394245

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.