ReviewCurrent atherosclerosis reports2023
Sex Differences in Familial Hypercholesterolemia.
Review in Current atherosclerosis reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Prevalence of Familial Hypercholesterolemia in Pakistan: A Pooled Analysis of 1.5 Million Individuals and Comparison with Other Countries of the Region.Global heart · 2025Pooled it
- What is the impact of lipid-lowering therapies on cardiovascular disease incidence among women with familial hypercholesterolaemia: A systematic review.Women's health (London, England) · on this mapPooled it
- From Phenotype to Genotype and Beyond: Insights into Familial Hypercholesterolemia and Familial Hypertriglyceridemia.Medicina (Kaunas, Lithuania) · 2026Review
- Menopause age and hypercholesterolemia comorbidities: a region-wide retrospective cohort study in Andalusia, Spain (2016-2022).BMJ open · 2026Observational
- Improving the clinical diagnosis of familial hypercholesterolemia among patients attending diabetes and cardiology clinics.American journal of preventive cardiology · 2026Article
- Sex Differences in Atherosclerosis and its Clinical Complications.Current atherosclerosis reports · 2026Review
- First LDLRAP1 and Recurrent LDLR Mutations in Tunisian Families With Familial Hypercholesterolemia.Journal of cellular and molecular medicine · 2026Article
- Prognostic stratification of familial hypercholesterolaemia patients using AI algorithms: a gender-specific approach.European heart journal. Digital health · 2025Article
- Monocytes from people with Familial Hypercholesterolaemia are inflammatory, despite statin-treatment.Atherosclerosis plus · 2025Article
- Sex differences in lipid profile and response to statin treatment in pediatric patients affected by familial hypercholesterolemia.European journal of pediatrics · 2025Observational
- The Potential Consideration of Implicit/Unconscious Gender Bias in Clinical Management Among Patients With Familial Hypercholesterolemia.Health science reports · 2025Article
- LDL cholesterol burden in elderly patients with familial hypercholesterolemia: Insights from real-world data.American journal of preventive cardiology · 2025Article
- Genetic Spectrum of Lithuanian Familial Hypercholesterolemia Patients.Journal of cardiovascular development and disease · 2025Article
- Prevalence of Severe Hypercholesterolemia and Familial Hypercholesterolemia Phenotype in Patients with Acute Coronary Syndrome.Medicina (Kaunas, Lithuania) · 2025Article
- Impact of Sex Differences on Lipids and Statin Utilization.Current atherosclerosis reports · 2025Review
- Sex-Based Disparities in Index Cases of Familial Hypercholesterolemia in Vietnam: A Cross-Sectional Study.Health science reports · 2025Article
- Association between the weight-adjusted-waist index and Familial hypercholesterolemia: a cross-sectional study.BMC cardiovascular disorders · 2024Article
- Targeted NGS Revealed Pathogenic Mutation in a 13-Year-Old Patient with Homozygous Familial Hypercholesterolemia: A Case Report.International journal of molecular sciences · 2024Article
- Lipoprotein Metabolism, Dyslipidemia, and Lipid-Lowering Therapy in Women: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Special Aspects of Cholesterol Metabolism in Women.Deutsches Arzteblatt international · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThis review aims to summarize the existing research on sex differences in familial hypercholesterolemia (FH) across the lifespan. RECENT
findingsFrom childhood onward, total- and low-density lipoprotein cholesterol (LDL-C) levels in girls are higher than those in boys with FH. By the age of 30 years, women with FH have a higher LDL-C burden than men. In adulthood, women are diagnosed later than men, receive less lipid-lowering treatment, and consequently have higher LDL-C levels. An excessive atherosclerotic cardiovascular disease risk is reported in young female compared to male FH patients. The periods of pregnancy and breastfeeding contribute to treatment loss and increased cholesterol burden. Earlier initiation of treatment, especially in girls with FH, and lifelong treatment during all life stages are important. Future research should aim to recruit both women and men, report sex-specific data, and investigate the impact of the female life course on cardiovascular outcomes. Future guidelines should include sex-specific aspects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.