Evidence map›Paper›PMID 37815618›Full record

ArticleEuropean journal of applied physiology2024

Changes in surrogate markers of intestinal epithelial injury and microbial translocation in young and older men during prolonged occupational heat stress in temperate and hot conditions.

Ben J Lee, Tessa R Flood, Natalia Galan-Lopez, James J McCormick, Kelli E King, Naoto Fujii, Glen P Kenny

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Article in European journal of applied physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Ben J LeeOccupational and Environmental Physiology Group, Centre for Sport, Exercise, and Life Sciences, Coventry University, Coventry, UK.
Tessa R FloodInstitute of Sport, Manchester Metropolitan University, Manchester, UK.
Natalia Galan-LopezOccupational and Environmental Physiology Group, Centre for Sport, Exercise, and Life Sciences, Coventry University, Coventry, UK.
James J McCormickHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, 125 University Ave., Room 367, Montpetit Hall, Ottawa, ON, K1N 6N5, Canada.
Kelli E KingHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, 125 University Ave., Room 367, Montpetit Hall, Ottawa, ON, K1N 6N5, Canada.
Naoto FujiiHealth and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Glen P KennyHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, 125 University Ave., Room 367, Montpetit Hall, Ottawa, ON, K1N 6N5, Canada. gkenny@uottawa.ca.ORCID http://orcid.org/0000-0001-8683-6973
University of Ottawa · CACoventry University · GBLoughborough University · GBManchester Metropolitan University · GBUniversity of Tsukuba · JP

Funding

Ontario Ministry of Labour 16-R-036
6 · The paper itself

Abstract

purposeExertional heat stress can cause damage to the intestinal epithelium and disrupt gastrointestinal barrier integrity, leading to microbial translocation (MT) linked to the development of heat stroke. This study aimed to assess age-related differences in markers of intestinal epithelial injury and MT following non-heat stress and high-heat stress exercise in healthy young and older men.

methodsMarkers of intestinal epithelial injury (intestinal fatty acid-binding protein-'IFABP') and MT (soluble cluster of differentiation 14-'sCD14'; and lipopolysaccharide-binding protein-'LBP') were assessed in healthy young (18-30 y, n = 13) and older (50-70 y) men (n = 12). Blood samples were collected before, after 180 min of moderate-intensity (metabolic rate: 200 W/m

resultsThere were no differences in IFABP and sCD14 between the young and older groups in the temperate condition, while LBP was greater in the older group (+ 0.66 ug/mL; + 0.08 to + 1.24 ug/mL). In the hot condition, the older group experienced greater increases in IFABP compared to the young group (+ 712 pg/mL/hr; + 269 to + 1154 pg/mL/hr). However, there were no clear between-group differences for sCD14 (+ 0.24 ug/mL/hr, - 0.22 to + 0.70 ug/mL/hr) or LBP (+ 0.86 ug/mL/hr, - 0.73 to + 2.46 ug/mL/hr).

conclusionWhile older men may experience greater intestinal epithelial injury following exercise in the heat; this did not lead to a greater magnitude of microbial translocation relative to their younger counterparts.

Indexed as

Heat Stress DisordersLipopolysaccharide ReceptorsAgedBiomarkersExerciseHeat-Shock ResponseHot TemperatureHumansMaleBiomarkersLipopolysaccharide ReceptorsAgeingHeat stressIFABPLBPPhysical activitysCD14

Identifiers

PMID37815618
OpenAlexW4387472523

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.