Evidence map›Paper›PMID 37815550›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2023

Role of histamine H

Silvia Sgambellone, Marta Febo, Mariaconcetta Durante, Silvia Marri, Serafina Villano, Oxana Bereshchenko, Graziella Migliorati, Emanuela Masini, Carlo Riccardi, Stefano Bruscoli and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Silvia SgambelloneSection of Pharmacology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139, Florence, Italy.
Marta FeboSection of Pharmacology, Department of Medicine and Surgery, University of Perugia, Piazzale Severi, 1 06132 S. Andrea Delle Fratte, Perugia, Italy.
Mariaconcetta DuranteSection of Pharmacology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139, Florence, Italy.
Silvia MarriSection of Pharmacology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139, Florence, Italy.
Serafina VillanoSection of Pharmacology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139, Florence, Italy.
Oxana BereshchenkoDepartment of Philosophy, Social Sciences and Education, University of Perugia, 06100, Perugia, Italy.
Graziella MiglioratiSection of Pharmacology, Department of Medicine and Surgery, University of Perugia, Piazzale Severi, 1 06132 S. Andrea Delle Fratte, Perugia, Italy.
Emanuela MasiniSection of Pharmacology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139, Florence, Italy.
Carlo RiccardiSection of Pharmacology, Department of Medicine and Surgery, University of Perugia, Piazzale Severi, 1 06132 S. Andrea Delle Fratte, Perugia, Italy.
Stefano BruscoliSection of Pharmacology, Department of Medicine and Surgery, University of Perugia, Piazzale Severi, 1 06132 S. Andrea Delle Fratte, Perugia, Italy.
Laura LucariniSection of Pharmacology, Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Gaetano Pieraccini, 6, 50139, Florence, Italy. laura.lucarini@unifi.it.
University of Florence · ITUniversity of Perugia · IT

Funding

Italian Ministry of University and Research (PRIN 2015 to EM and CR) PRIN 2015
6 · The paper itself

Abstract

introductionThis study investigates the interactions between histaminergic system and glucocorticoid-induced leucin zipper (GILZ) in the inflammatory process and glucocorticoid modulation in lung fibrosis.

methodsWild-type (WT) and GILZ Knock-Out (KO) mice were treated with bleomycin (0.05 IU) or saline, delivered by intra-tracheal injection. After surgery, mice received a continuous infusion of JNJ7777120 (JNJ, 2 mg/kg b.wt.) or vehicle for 21 days. Lung function was studied by measuring airway resistance to air insufflation through the analysis of pressure at airway opening (PAO). Lung samples were collected to evaluate the expression of histamine H

resultsAirway fibrosis and remodeling were assessed by measuring TGF-β production and α-SMA deposition. JNJ reduces PAO in WT but not in GILZ KO mice (from 22 ± 1 mm to 15 ± 0.5 and from 24 ± 1.5 to 19 ± 0.5 respectively), MPO activity (from 204 ± 3.13 pmol/mg to 73.88 ± 2.63 in WT and from 221 ± 4.46 pmol/mg to 107 ± 5.54 in GILZ KO), the inflammatory response, TGF-β production, and α-SMA deposition in comparison to WT and GILZ KO vehicle groups.

conclusionIn conclusion, the role of H

Indexed as

GlucocorticoidsPulmonary FibrosisAnimalsAnti-Inflammatory AgentsHistamineMiceReceptors, HistamineTranscription FactorsTransforming Growth Factor betaAnti-Inflammatory AgentsGlucocorticoidsHistamineReceptors, HistamineTranscription FactorsTransforming Growth Factor betaGILZGlucocorticoidsHistaminergic systemInflammationPulmonary fibrosis

Identifiers

PMID37815550
PMCPMC10611623
OpenAlexW4387472213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.