Evidence map›Paper›PMID 37815528›Full record

ArticleGut microbes2023

Identification of a functional peptide of a probiotic bacterium-derived protein for the sustained effect on preventing colitis.

Harpreet Kaur, Syed Azmal Ali, Sarah P Short, Christopher S Williams, Jeremy A Goettel, M Kay Washington, Richard M Peek, Sari A Acra, Fang Yan

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression.International journal of biological sciences · 2026
    Review
  4. Review
  5. Review
  6. Molecular Mechanisms ofMicroorganisms · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Harpreet KaurDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Syed Azmal AliDivision of Proteomics of Stem Cell and Cancer, German Cancer Research Center, Heidelberg, Germany.
Sarah P ShortDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Christopher S WilliamsDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeremy A GoettelDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
M Kay WashingtonDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Richard M PeekDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Sari A AcraDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Fang YanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-4959-2433
Vanderbilt University Medical Center · USGerman Cancer Research Center · DEVanderbilt University · US

Funding

Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2009 to 2026
$27.5M
COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8M
H.Pylori Relationship to Digestive Diseases and CancerR01CA077955 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2003 to 2026
$9.7M
Helicobacter Pylori and Gastrointestinal BiologyR01DK058587 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PEEK, RICHARD M. · 2001 to 2024
$7.8M
Regulation of intestinal development by a Lactobacillus GG-derived proteinR01DK081134 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI YAN, FANG · 2009 to 2023
$4.7M
Antioxidant regulation of intestinal homeostasis and diseaseK01DK123495 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHORT, SARAH PALMER · 2020 to 2024
$732k
Investigating the Role of IL-23R in Mucosal Regulatory T CellsR03DK123489 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOETTEL, JEREMY ALLEN · 2020 to 2021
$260k
NCI NIH HHS P01 CA116087NCI NIH HHS R01 CA077955NIDDK NIH HHS K01 DK123495NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK058587NIDDK NIH HHS R01 DK081134NIDDK NIH HHS R03 DK123489NIDDK NIH HHS RC2 DK118640
6 · The paper itself

Abstract

Several probiotic-derived factors have been identified as effectors of probiotics for exerting beneficial effects on the host. However, there is a paucity of studies to elucidate mechanisms of their functions. p40, a secretory protein, is originally isolated from a probiotic bacterium,

Indexed as

ColitisGastrointestinal MicrobiomeProbioticsAdultAnimalsBacterial ProteinsHumansMicePeptidesBacterial ProteinsPeptidesHistone methyltransferaseintestinal epithelial cellp40Setd1βTGFβ

Identifiers

PMID37815528
PMCPMC10566403
OpenAlexW4387472993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.