Evidence map›Paper›PMID 37814997›Full record

ArticleHead & neck2023

CAD/CAM-assisted ablative surgery and intraoperative brachytherapy for pediatric skull-base sarcomas.

Joseph Lopez, Tejas Subramanian, Hilda Stambuk, Mark Schreyer, Robbie Woods, Daniel Scholfield, Richard Wong, Marc A Cohen, Jatin Shah, Ian Ganly

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Joseph LopezDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.ORCID 0000-0003-3001-1109
Tejas SubramanianDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.ORCID 0000-0003-0323-6716
Hilda StambukDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mark SchreyerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Robbie WoodsDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.
Daniel ScholfieldDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.
Richard WongDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.
Marc A CohenDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.ORCID 0000-0002-6104-7967
Jatin ShahDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.
Ian GanlyDepartment of Surgery, Division of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center New York, New York, New York, USA.ORCID 0000-0001-7636-5426
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundHead and neck (H&N) sarcomas in children can poise numerous challenges to the surgical oncologist and require multidisciplinary input and meticulous surgical planning. The application of computer-assisted design/computer-assisted manufacturing (CAD/CAM) has been extensively examined in H&N reconstruction in adults, but its utility in ablative oncologic surgery in children warrants further examination. We present preliminary results utilizing CAD/CAM techniques to assist in planning tumor resections and the application of intra-operative radiation in children with skull-base sarcomas.

methodsA retrospective cohort review of all pediatric patients who presented to a tertiary care cancer center for surgical resection of a skull-base malignancy was performed between 1980 and 2021. All children under 18 years of age with diagnosis of a skull-base sarcoma as confirmed with imaging and pathology were analyzed.

resultsA total of 21 children were identified but only four children with skull-base sarcomas had diagnostic imaging available in whom computer-assisted volumetric analyses were generated. In these cases, CAD/CAM was used to plan surgical approaches and intraoperative radiotherapy, significantly aiding in treatment for these complicated pediatric cases.

conclusionCAD/CAM planning for oncologic resection has huge potential. Here we have shown its utility in pre-operative surgical planning and for administration of intraoperative radiation therapy. Future studies are needed to examine its value in facilitating intraoperative surgical management and patient outcomes, as well as cost effectiveness.

Indexed as

BrachytherapyHead and Neck NeoplasmsPlastic Surgery ProceduresSarcomaSurgery, Computer-AssistedAdolescentAdultChildComputer-Aided DesignHumansRetrospective StudiesSkullbrachytherapyCAD/CAMoperative techniquespediatricsskull base

Identifiers

PMID37814997
PMCPMC11187774
OpenAlexW4387473249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.