Evidence map›Paper›PMID 37814858›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[miRNA-128-3p inhibits malignant behavior of glioma cells by downregulating KLHDC8A expression].

Zhengtao Yu, Jiameng Li, Junwen Jiang, You Li, Long Lin, Ying Xia, Lei Wang

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Translational cancer research · 2026
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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zhengtao YuDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya School of Central South University, Haikou 570208, China.
Jiameng LiDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya School of Central South University, Haikou 570208, China.
Junwen JiangDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya School of Central South University, Haikou 570208, China.
You LiDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya School of Central South University, Haikou 570208, China.
Long LinDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya School of Central South University, Haikou 570208, China.
Ying XiaDepartment of Neurosurgery, Affiliated Haikou Hospital of Xiangya School of Central South University, Haikou 570208, China.
Lei WangDepartment of Neurosurgery, Hunan Cancer Hospital and Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410006, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether miRNA-128-3p regulates malignant biological behavior of glioma cells by targeting KLHDC8A.

methodsDual-luciferase reporter assays, qRT-PCR and Western blotting were used to verify the targeting of miRNA-128-3p to KLHDC8A. Edu assay, flow cytometry, Transwell assay and would healing assay were used to determine the effects of changes in miRNA-128-3p and KLHDC8A expression levels on malignant behavior of glioma cells. Rescue experiment was carried out to verify that miRNA-128-3p regulated glioma cell proliferation, apoptosis, invasion and migration by targeting KLHDC8A.

resultsThe expression level of KLHDC8A was significantly increased in high-grade glioma tissue and was closely related to a poor survival outcome of the patients. Overexpression of KLHDC8A promoted glioma cell proliferation, migration and invasion, and miRNA-128-3p overexpression inhibited proliferative and metastatic capacities of glioma cells. Mechanistically, KLHDC8A expression was directly modulated by miRNA-128-3p, which, by targeting KLHDC8A, inhibited malignant behavior of glioma cells.

conclusionUpregulation of miRNA-128-3p inhibits uncontrolled growth of glioma cells by negatively regulating KLHDC8A expression and its downstream effectors, suggesting that the miRNA-128-3p-KLHDC8A axis may serve as a potential prognostic indicator and a therapeutic target for developing new strategies for glioma treatment.

Indexed as

GliomaMicroRNAsApoptosisCell Cycle ProteinsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansUp-RegulationCell Cycle ProteinsKLHDC8A protein, humanMicroRNAsMIRN128 microRNA, humanbiomarkergliomaKLHDC8AmigrationmiRNA-128-3pproliferation

Identifiers

PMID37814858
PMCPMC10563106
OpenAlexW4387473216

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.