ReviewCureus2023
Elucidating the Mechanisms of Pulsed Radiofrequency for Pain Treatment.
Review in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 11 citations in OpenAlex.
- Oxycodone combined with pulsed radiofrequency for refractory cancer pain from spinal metastases: a randomized controlled study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Efficacy and Safety of Dorsal Root Ganglion Pulse Radiofrequency Combined With Sympathetic Radiofrequency Ablation in the Treatment of Acute Herpetic Neuralgia.The Clinical journal of pain · 2026Trial
- Pulsed Radiofrequency of the Sacral Dorsal Root Ganglia as a Potential Rescue Therapy for Refractory Chronic Pelvic Pain: A Case Series.The American journal of case reports · 2026Article
- Article
- Duration Dependent Outcomes of Combined Dorsal Root Ganglion Pulsed Radiofrequency and Epidural Steroid Injection in Chronic Lumbosacral Radicular Pain.Journal of clinical medicine · 2026Article
- Effect of Pulsed Radiofrequency with Various Time-Course on Rheumatoid Arthritis Joint Pain in Rats.Journal of pain research · 2026Article
- A Novel Single-Puncture Ultrasound-Guided Approach for Radiofrequency Treatment of the Articular Branches of Femoral and Obturator Nerves.Journal of pain research · 2026Article
- Combined ultrasound-guided C2 DRG pulsed radiofrequency and suboccipital myofascial plane block for cervicogenic headache: a retrospective study.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- A Study on the Efficacy and Safety of Intravenous Lidocaine Infusion Combined with Pulsed Radiofrequency in Preventing Postherpetic Neuralgia: A Randomized, Double-Blind, Controlled Trial.Journal of pain research · 2026Article
- Article
- Efficacy and safety of ultrasound-guided pulsed radiofrequency for cervicogenic headache: a retrospective study focusing on the C2 dorsal root ganglion at the C1-2 level.Journal of oral & facial pain and headache · 2025Article
- Pain Decrement Using Radiofrequency Therapy After Knee Platelet-Rich Plasma Injections Within First 72 h in Active Populations with Patellar Chondropathy.Journal of clinical medicine · 2025Article
- Efficacy and Safety of Pulsed Radiofrequency Combined with Platelet-Rich Plasma in the Treatment of Postherpetic Neuralgia: A Systematic Review and Meta-Analysis.Journal of pain research · 2025Review
- Transforaminal Steroid Injection After Dorsal Root Ganglion Pulsed Radiofrequency (DRG-PRF): Impact on Pain Intensity and Disability.Pain and therapy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulsed radiofrequency is a well-documented treatment option for multiple painful conditions where pulses of energy are delivered close to neural elements. Since its earliest adoption, this technique has gained increasing acceptance as a minimally invasive procedure, and new applications are evolving. Studies have shown microscopic and biochemical changes that reflect beneficial effects; however, the exact mechanism of action is not yet completely understood. To redress this paucity, 11,476 articles of scientific relevance published between 1980 and November 2022 were mined through a search of the PubMed database, arriving at 49 studies both in animals and humans. In general, the experimental studies examined have shown that pulsed radiofrequency induces multiple changes with antinociceptive and neuromodulatory effects. These modifications include changes in neural and glial cells, synaptic transmission, and perineural space. Studies also reveal that pulsed radiofrequency regulates inflammatory responses, cellular signaling proteins, and the expression of genes related to pain transmission, acting in biological processes in structures such as myelin, mitochondria, axons, glial cells, connective tissue, regulation of proteins, ion channels, and neurotransmitters.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.