Evidence map›Paper›PMID 37814730›Full record

ArticleCureus2023

Measuring Salivary Cortisol to Assess the Effect of Natural Environments on Stress Level in Acute Patients With Severe Brain Injuries: An Exploratory Study.

Jane Jöhr, Tania Martinez, Renaud Marquis, Stephen Bruce, Pierre-Alain Binz, Sabine Rey, Gaël Hafner, Caroline Attwell, Karin Diserens

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jane JöhrDepartment of Clinical Neurosciences/Neurology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Tania MartinezDepartment of Clinical Neurosciences/Neurology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Renaud MarquisDepartment of Clinical Neurosciences/Neurology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Stephen BruceLaboratory of Clinical Chemistry/Biomedicine, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Pierre-Alain BinzLaboratory of Clinical Chemistry/Biomedicine, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Sabine ReyDepartment of Clinical Neurosciences/Neurology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Gaël HafnerDepartment of Clinical Neurosciences/Neurology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Caroline AttwellDepartment of Clinical Neurosciences/Neurology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
Karin DiserensDepartment of Clinical Neurosciences/Neurology, Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Lausanne, CHE.
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalivary cortisol is a safe and non-invasive measure of hypothalamic-pituitary-adrenal axis function and is used as a biomarker of the human stress response. Natural environments are recognized to contribute to help reduce the effect of stress.

objectiveTo determine the feasibility of a salivary cortisol collection protocol for acute severely brain-injured patients, and to explore the influence of exposure to natural settings on salivary cortisol concentration as an index of stress level.

methodsAn exploratory study on 17 acute patients with severe brain injury was performed. We collected salivary samples in a closed hospital ward and a therapeutic garden at the start of the session and after 30 minutes of rest time. Physiological parameters, level of communication, and subjective well-being were also assessed.

resultsThe primary objectives regarding the feasibility of the protocol were met overall. We found no significant differences in cortisol values when including the whole population. However, cortisol values were significantly higher in the indoor environment in patients with communication attempts.

conclusionsA salivary collection protocol with brain-injured patients in the acute phase is feasible and safe, and this type of measurement could pave the way for future research supporting the benefits of nature as an additional resource in their neurorehabilitation.

Indexed as

acute phasebrain injurynatureneurorehabilitationsalivary cortisolstress

Identifiers

PMID37814730
PMCPMC10560321
OpenAlexW4386544902

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.