Evidence map›Paper›PMID 37814355›Full record

ArticleActa obstetricia et gynecologica Scandinavica2023

Sacral neuromodulation in endometriosis - A promising treatment option for chronic pelvic pain.

Adrian Zegrea, Emilia Ojala, Pia Suvitie, Pirita Varpe, Heikki Huhtinen, Johanna Mäkelä-Kaikkonen, Tero Rautio, Päivi Härkki, Sinikka Salmenkylä, Mika Ukkonen and 2 more

Open access · diamondAbstract readMulticenter Study
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Adrian ZegreaSeinäjoki Central Hospital, Seinäjoki, Finland.ORCID 0000-0002-7458-9386
Emilia OjalaTurku University Hospital and University of Turku, Turku, Finland.
Pia SuvitieTurku University Hospital and University of Turku, Turku, Finland.ORCID 0000-0002-8729-4448
Pirita VarpeTurku University Hospital and University of Turku, Turku, Finland.
Heikki HuhtinenTurku University Hospital and University of Turku, Turku, Finland.
Johanna Mäkelä-KaikkonenOulu University Hospital, Oulu Medical Research Center, Oulu, Finland.
Tero RautioOulu University Hospital, Oulu Medical Research Center, Oulu, Finland.
Päivi HärkkiHelsinki University Hospital and University of Helsinki, Helsinki, Finland.
Sinikka SalmenkyläHelsinki University Hospital and University of Helsinki, Helsinki, Finland.
Mika UkkonenTampere University Hospital and University of Tampere, Tampere, Finland.
Maija LavoniusTurku University Hospital and University of Turku, Turku, Finland.
Tarja PintaSeinäjoki Central Hospital, Seinäjoki, Finland.
University of Turku · FIOulu University Hospital · FISeinäjoki University of Applied Sciences · FIUniversity of Helsinki · FITampere University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic pelvic pain (CPP) affects over one fifth of women worldwide, and endometriosis is one of the most common causes. In the present study, we examined whether sacral neuromodulation (SNM) is effective in the treatment of refractory chronic pelvic pain in women with endometriosis. MATERIAL AND

methodsThis multicenter prospective pilot study was started in 2017 and includes patients with chronic pelvic pain with no other obvious pathology than endometriosis. Other treatment options have been tried or they are unsuitable. Patients underwent SNM implantation. The main outcome was postoperative pain reduction and secondary outcome was quality of life. The following questionnaires were used to assess the outcomes: Brief pain inventory (BPI), clinical global impression - improvement (CGI-I), 15D-measure of health-related quality of life, and Biberoglu and Behrman (B&B) score.

resultsA total of 35 patients underwent the SNM procedure and, at the time of analysis, 15 patients had returned one-year questionnaires. The patients had a history of endometriosis for a median of 5.5 (interquartile range 2-9) years, with no correlation between the severity of symptoms and the duration of the disease (p = 0.158). A total of 31 patients (89%) were implanted with the internal pulse generator. There were statistically significant changes in BPI pain-related items. Worst experienced daily pain decreased among those who returned 12-month questionnaires from median 9 to 5 (p = 0.006), average daily pain from 6 to 3.5 (p = 0.004), and least daily pain from 3 to 1 (p = 0.004). Based on the CGI questionnaire (n = 14), at 12 months nine patients (60%) experienced great improvement in their symptoms, three patients (20%) much improvement and two patients (13%) minimal improvement. None of the patients experienced worsening of their symptoms. There was a statistically significant change in overall 15D score at 1 month (p < 0.001), 6 months (p = 0.001) and 12 months (p = 0.018), when the results were compared to baseline values. Median B&B score also improved significantly and decreased from a baseline value of 8 (4-12) to 4.5 (0-6), p = 0.002.

conclusionsBased on the preliminary findings of our study, SNM might be a promising treatment of CPP in endometriosis patients.

Indexed as

Chronic PainElectric Stimulation TherapyEndometriosisFemaleHumansPelvic PainPilot ProjectsProspective StudiesQuality of LifeTreatment Outcomechronic painendometriosispelvic painsacral neuromodulation

Identifiers

PMID37814355
PMCPMC10619602
OpenAlexW4387472593

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.