ArticleEuropean journal of medical research2023
Survival analysis of age-related oral squamous cell carcinoma: a population study based on SEER.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic performance of convolutional neural network-based AI in detecting oral squamous cell carcinoma: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Deep learning-based automated detection of oral squamous cell carcinoma in histopathological images: a comparative study of five CNN architectures.Odontology · 2026Article
- Effect of miR-214-3p on Cisplatin Resistance in Oral Squamous Cell Carcinoma by Regulating Ferroptosis Through Targeting GPX4.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Lymphocyte-to-Monocyte Ratio in Oral Squamous Cell Carcinoma.Diagnostics (Basel, Switzerland) · 2026Article
- Immunological Analysis of Oral Cytobrush Specimens for Early Detection of Oral Cancer Biomarkers: A Comprehensive Review.International journal of molecular sciences · 2026Review
- Resveratrol in Oral Squamous Cell Carcinoma: Preclinical Evidence and Translational Opportunities.Oncology research · 2026Review
- Frequency of Oral Squamous Cell Carcinoma in Two Public Hospitals in Peru: A Ten-Year Retrospective Study.Oral health & preventive dentistry · 2025Article
- Deep learning-based artificial intelligence models predict survival in patients with oral cavity squamous cell carcinoma.Scientific reports · 2025Article
- Reappraising the TNM staging system for oral cavity squamous cell carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Research on the expression, prognostic value, and regulatory effects on immune microenvironment of NETO2 in oral squamous cell carcinoma.BMC cancer · 2025Article
- Evaluation of salivary and serum Exosomal mRNAs as biomarkers for the diagnosis and prognosis of oral squamous cell carcinoma.Scientific reports · 2025Article
- Preoperative Diagnostic Value of Spectral CT for Predicting Perineural Invasion in Esophageal Cancer.Cancer medicine · 2025Article
- Impact of Staging, Histologic Grading, and Racial Background on Lip Cancer Survival in the United States: Insights from the SEER Database (2010-2020).Cancer research communications · 2025Article
- Identification of Non-Invasive Diagnostic Markers for Oral Squamous Cell Carcinoma Through Salivary Microbiome and Gene Expression Analysis.International journal of molecular sciences · 2025Article
- Association of ALDH3A1 expression with tumor differentiation, pathological stage, and nodal status in oral squamous cell carcinoma.Journal of Taibah University Medical Sciences · 2025Article
- HPV Infection and Oral Microbiota: Interactions and Future Implications.International journal of molecular sciences · 2025Review
- Curcumin and its Analogues in Oral Squamous Cell Carcinoma: State-of-the-art and Therapeutic Potential.Anti-cancer agents in medicinal chemistry · 2025Review
- Assessment of a Bioimpedance-Based Method for the Diagnosis of Oral Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Polyamines in Dysbiotic Oral Conditions of Older Adults: A Scoping Review.International journal of molecular sciences · 2024Article
- Survival outcomes and contributing factors in oral squamous cell carcinoma patients in Khuzestan province, southwest of Iran.Frontiers in oncology · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThis research aimed to investigate the prognostic factors of oral squamous cell carcinoma (OSCC), especially the role of age.
methodsA total of 33,619 cases of OSCC were received from the Surveillance, Epidemiology, and End Results (SEER) database during 2005-2015. Kaplan-Meier curves of 5-year overall survival rates and 5-year cancer-specific survival rates were performed, and univariate and multivariate Cox regression analyses as well as competing risk model were used to help understand the relationship between various factors and mortality of OSCC.
resultsCompared to 18-39-year-old group, the older age was an important predictor of worse prognosis. The multivariate analysis of overall survival (OS) was 50-59 years (HR, 1.32; 95% CI 1.17-1.48; p ≤ .001), 60-69 years (HR, 1.66; 95% CI 1.42-1.87; p ≤ .001) and 70 + years (HR, 3.21; 95% CI 2.86-3.62; p ≤ .001), respectively, while the specific value of competing risk model was 60-69 years (HR, 1.21; 95% CI 1.07-1.38; p = .002) and 70 + years (HR, 1.85; 95% CI 1.63-2.10; p ≤ .001). In addition, female gender, unmarried, Blacks, tumor in floor of mouth, size and higher Tumor Node Metastasis (TNM) classification were also other predictors that signify significant clinically deterioration of OS/cancer-specific survival (CSS).
conclusionsOur research revealed that age was an important factor in explaining the difference of survival in the whole process of OSCC. It is suggested that we should pay attention to the influence of age on diagnosis, treatment and prognosis in the clinical process.
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