ArticleNature chemistry2023
Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes.
Article in Nature chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 53 citations in OpenAlex.
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- Conjugated Macrocycles for Host-Guest Recognition and Optoelectronic Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Reversible Exfoliation-Aggregation Dynamics in Ionic COFs for Tunable Interfacial Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Artificial Transmembrane Channels for Selective Ascorbic Acid Transport and Bioorthogonal Signal Transduction.Angewandte Chemie (International ed. in English) · 2026Article
- Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels.Angewandte Chemie (International ed. in English) · 2026Article
- Quinoline-Directed Folding in Anilide-Quinoline Hybrids: Length-Controlled Three-Dimensional Conformational Diversity.JACS Au · 2026Article
- Steric Control of Cooperative Anion Transport Mediated by β- and δ‑Hexachlorocyclohexane Multivalent Carriers.JACS Au · 2026Article
- Fast-switching pH-responsive biomimetic ion channels with bidirectional gating control.Chemical science · 2026Article
- Near-Infrared Triggered Anion Transport Induces Cancer Cell Death.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Supramolecular macrocyclic artificial ion channels for biomedical applications.Fundamental research · 2025Review
- Molecular prosthetics for CFTR designed for anion selectivity outperform amphotericin B in cultured cystic fibrosis airway epithelia.bioRxiv : the preprint server for biology · 2025Article
- Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems.Angewandte Chemie (International ed. in English) · 2025Review
- Insertion of anthranilyl unit into inert amides: A facile route to oligoamides and cyclic peptides.Science advances · 2025Article
- Carbazole Framework as Functional Scaffold for the Design of Synthetic Receptors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Probing the Reversible Binding of Anionic Reactive Sulfur and Nitrogen Species in Imidazolium Receptors with Directional C-H Hydrogen Bonds.Inorganic chemistry · 2025Article
- Unraveling cooperative interactions between complexed ions in dual-host strategy for cesium salt separation.Beilstein journal of organic chemistry · 2025Article
- Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system.RSC advances · 2024Article
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Authors and funding
17 authors at 5 institutions in 2 countries.
Funding
Abstract
The convergent positioning of functional groups in biomacromolecules leads to good binding, catalytic and transport capabilities. Synthetic frameworks capable of convergently locking functional groups with minimized conformational uncertainty-leading to similar properties-are highly desirable but rare. Here we report C5-symmetric aromatic pentaamide macrocycles synthesized in one pot from the corresponding monomers. Their crystal structures reveal a star-shaped, fully constrained backbone that causes ten alternating NH/CH hydrogen-bond donors and five large amide dipoles to orient towards the centre of the macrocycle. With a highly electropositive cavity in a high-energy unbound state, the macrocycles bind anions in a 1:1 stoichiometry in solution, with high affinity for halides and very high affinity for oxoanions. We demonstrate that such macrocycles are able to transport anions across lipid bilayers with a high chloride selectivity and restore the depleted airway surface liquid of cystic fibrosis airway cell cultures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.