SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2024
Bone density and fracture risk factors in ankylosing spondylitis: a meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Prevalence and relative risk of fractures and osteoporosis in patients with ankylosing spondylitis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Pooled it
- The effect of acupuncture-related therapies in animal model of postmenopausal osteoporosis: a meta-analysis and data mining approach.Frontiers in endocrinology · 2025Pooled it
- Management of glucocorticoid-induced osteoporosis in rheumatic diseases.Best practice & research. Clinical rheumatology · 2026Review
- Modified anterior long-segment fixation versus posterior and combined approaches for subaxial cervical fractures in ankylosing spondylitis: a retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Predictors of hidden blood loss in ankylosing spondylitis patients receiving spinal deformity correction: osteotomy selection, bone density, and preoperative platelets.Spine deformity · 2026Article
- Bone health in young adults with inflammatory arthritis: assessment of associated factors of low bone mineral density.Archives of osteoporosis · 2026Article
- Clinical presentation and rehabilitation approaches in patients with ankylosing spondylitis and comorbidities: a multicenter retrospective study.Rheumatology international · 2026Article
- Diagnostic utility of serum TRACP5b for secondary osteoporosis in ankylosing spondylitis: a comparative cross-sectional study with primary osteoporosis and healthy controls.Clinical rheumatology · 2026Article
- Community-based epidemiological study on the prevalence and health status of Spondyloarthritis in residents of Wuyuan County, China, 2023.Rheumatology and immunology research · 2026Article
- Case Report: Reconstruction of the chest wall with titanium alloy plates after resection of a rare malignant spindle cell tumor of the sternum complicated by ankylosing spondylitis.Frontiers in surgery · 2026Article
- Sandwich strategy for the treatment of kyphosis with scoliosis and bilateral hip ankylosis in ankylosing spondylitis: a case report.Frontiers in surgery · 2026Article
- Impact of immunosuppressive therapy and clinical risk factors on the prevalence of low bone mineral density in rheumatic diseases.Frontiers in medicine · 2026Article
- Ankylosing spondylitis complicated by cervical spine fracture and cervicothoracic epidural hematoma: A case report.Medicine · 2025Article
- Increased Osteocyte Lacunae Size and Organic Matrix Pyridinoline Content in Transiliac Bone from Patients with Axial Spondyloarthritis (axSpA).Calcified tissue international · 2025Article
- Prognostic value of trabecular bone score for major osteoporotic fractures in patients with radiographic axial spondyloarthritis: a 3-year prospective cohort study.Rheumatology international · 2025Article
- Posterior treatment of ankylosing spinal diseases with thoracolumbar fractures: a network meta-analysis.BMC musculoskeletal disorders · 2025Article
- Low Bone Turnover, Mineralization Impairment, and Cortical Alterations in Patients with Axial Spondyloarthritis: A Histomorphometric Study.Calcified tissue international · 2025Article
- Answer to the letter to the editor of W. Tang, et al. concerning "Impact of preoperative back pain severity on PROMIS outcomes following minimally invasive lumbar decompression" by Anwar FN, et al. (Eur Spine J [2024]: doi: 10.1007/s00586-024-08275-w).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Anti-Osteoporosis Is Imperative in Prevention of Progress of Ankylosing Spondylitis.International journal of general medicine · 2025Article
- The Paradox of Osteoporosis in Spondyloarthropathies.Mediterranean journal of rheumatology · 2024Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We included 39 studies in our meta-analysis, finding that patients with ankylosing spondylitis (AS) exhibit decreased bone mineral density (BMD) and an elevated risk of fractures. Additionally, we analyzed the risk factors associated with fractures in these patients.
introductionAS is a chronic inflammatory disease primarily affecting the spine and sacroiliac joints, with reduced BMD, osteoporosis, and fractures being common complications. This study aims to systematically consolidate and conduct a meta-analysis of existing research to comprehensively understand decreased bone mineral density, osteoporosis, and fracture risks at various anatomical sites in AS patients. The objective is to provide reliable information for the management of AS patients and to inform clinical decision making.
methodsWe conducted a thorough search in various databases including Embase, PubMed, Cochrane Library, and Web of Science. These studies focused on the risk of and risk factors for decreased BMD, osteopenia, osteoporosis, and fractures at different sites among AS patients such as the lumbar spine and femoral neck. The quality of eligible studies was evaluated. Sensitivity analysis was performed to assess the reliability of our analysis results and understand the effects of individual studies on the heterogeneity across studies.
resultsA total of 39 studies were included. Our meta-analysis results revealed significant differences between AS patients and healthy controls. AS patients had significantly lower BMDs at the femoral neck, hip, lumbar vertebra 2 (L2), lumbar vertebra 3 (L3), and lumbar vertebra 4 (L4), but higher BMDs at 1/3 distal radius and ultra distal radius. Risk factors for fractures among AS patients included old age, long course of disease, and low BMD at the lumbar spine. In contrast, factors such as erythrocyte sedimentation rate (ESR), the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score, gender, and body mass index (BMI) were not risk factors for fractures in AS patients.
conclusionOur study highlights that BMD at the femoral neck is more effective for evaluating AS patients compared with the BMD at the lumbar spine. Additionally, the risk of osteoporosis and fractures in AS patients is higher in younger patients and those at the early stage of this disease.
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