Evidence map›Paper›PMID 37814025›Full record

ReviewNature neuroscience2023

Studying the neural representations of uncertainty.

Edgar Y Walker, Stephan Pohl, Rachel N Denison, David L Barack, Jennifer Lee, Ned Block, Wei Ji Ma, Florent Meyniel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Towards an integrative neuroscience of metacognition.Nature reviews. Neuroscience · 2026
    Review
  2. Article
  3. Article
  4. Review
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  6. Cortical deviance detection represents a canonical difference signal.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Uncertainty, Not Mental Content, Drives Dorsomedial Prefrontal Engagement during Inferences about Others.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Article
  15. Article
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  17. An entropic explanation of insistence on sameness in autism.Frontiers in computational neuroscience · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edgar Y Walker *Department of Physiology and Biophysics, Computational Neuroscience Center, University of Washington, Seattle, WA, USA.
Stephan Pohl *Department of Philosophy, New York University, New York, NY, USA.
Rachel N DenisonDepartment of Psychological & Brain Sciences, Boston University, Boston, MA, USA.ORCID 0000-0002-6304-5236
David L BarackDepartment of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7131-4638
Jennifer LeeCenter for Neural Science, New York University, New York, NY, USA.
Ned BlockDepartment of Philosophy, New York University, New York, NY, USA.ORCID 0000-0003-0587-6899
Wei Ji MaCenter for Neural Science, New York University, New York, NY, USA.ORCID 0000-0002-9835-9083
Florent MeynielCognitive Neuroimaging Unit, INSERM, CEA, CNRS, Université Paris-Saclay, NeuroSpin center, Gif-sur-Yvette, France. florent.meyniel@cea.fr.ORCID 0000-0002-6992-678X

Funding

Agence Nationale de la Recherche (French National Research Agency) 18-CE37-0010-01EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) StG-947105
6 · The paper itself

Abstract

The study of the brain's representations of uncertainty is a central topic in neuroscience. Unlike most quantities of which the neural representation is studied, uncertainty is a property of an observer's beliefs about the world, which poses specific methodological challenges. We analyze how the literature on the neural representations of uncertainty addresses those challenges and distinguish between 'code-driven' and 'correlational' approaches. Code-driven approaches make assumptions about the neural code for representing world states and the associated uncertainty. By contrast, correlational approaches search for relationships between uncertainty and neural activity without constraints on the neural representation of the world state that this uncertainty accompanies. To compare these two approaches, we apply several criteria for neural representations: sensitivity, specificity, invariance and functionality. Our analysis reveals that the two approaches lead to different but complementary findings, shaping new research questions and guiding future experiments.

Indexed as

NeurosciencesUncertainty

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.