ArticleNature immunology2023
The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate.
Open access · hybridAbstract read
In one paragraph
Article in Nature immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Glutamine-driven metabolic reprogramming promotes CAR-T cell function through mTOR-SREBP2 mediated HMGCS1 upregulation in ovarian cancer.Journal of translational medicine · 2025Trial
- A pH-Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti-senescence.Smart molecules : open access · 2026Article
- PRMT3-Mediated Arginine Methylation Stabilizes PCSK9 to Promote Aortic Valve Calcification.Circulation · 2026Article
- Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies.Genes & diseases · 2026Review
- Redox index and capacity analysis (RICA) reveals NAD biology changes in T cell responses in vitro and ex vivo.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- CD8Cancer cell international · 2026Review
- Methionine metabolism is linked with phospholipid and glutamine metabolism to drive ferroptosis.Cell reports · 2026Article
- Aspartate availability drives differential engagement of the malate-aspartate shuttle.Molecular cell · 2026Article
- Metabolites beyond metabolism: Exploring their atypical roles in protein modification and signaling transduction.Chinese medical journal · 2026Review
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Multi-omics revealed GOT1/ALDH3A1 pathway attenuated head and neck squamous cell carcinoma and increased cisplatin sensitivity through ROS induced by mitochondrial dysfunction.Redox report : communications in free radical research · 2025Article
- Ammonia in cancer: dual roles and therapeutic strategies.Cancer cell international · 2025Review
- Malate targets pyruvate kinase M2 to promote colorectal cancer cell cycle arrest and tumor suppression.Molecular biomedicine · 2025Article
- Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy.Molecular cancer · 2025Review
- Ammonia Suppresses the Antitumor Activity of Natural Killer Cells and T Cells by Decreasing Mature Perforin.Cancer research · 2025Article
- α-Ketoglutarate alleviates the pathogenesis of lupus and inhibits the activation and differentiation of B cells by promoting the expression of CD39.Cellular and molecular life sciences : CMLS · 2025Article
- Metabolic Dialogue Shapes Immune Response in the Tumor Microenvironment.European journal of immunology · 2025Review
- High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs.Frontiers in immunology · 2025Article
- Glutamine metabolism and ammonia death: targeted modulation for enhanced cancer immunotherapy.Frontiers in immunology · 2025Review
- GATD3A-deficiency-induced mitochondrial dysfunction facilitates senescence of fibroblast-like synoviocytes and osteoarthritis progression.Nature communications · 2024Article
Corrections and comments
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Authors and funding
20 authors at 4 institutions in 3 countries.
Nina WeisshaarT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sicong MaInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Yanan MingInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China.
Alaa MadiT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0003-0744-4360
Alessa MiegT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Marvin HeringT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ferdinand ZettlT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kerstin MohrT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nora Ten BoschT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Diana StichlingT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michael BuettnerMetabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.
Gernot PoschetMetabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-5344-0865
Glynis KlinkeMetabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.ORCID 0000-0003-2095-4437
Michael SchulzMetabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.
Nina Kunze-RohrbachMetabolomics Core Technology Platform, Centre for Organismal Studies (COS), Heidelberg University, Heidelberg, Germany.
Carolin KerberTissue Bank of the German Center for Infection Research (DZIF), Partner Site Heidelberg, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Isabel Madeleine KleinTissue Bank of the German Center for Infection Research (DZIF), Partner Site Heidelberg, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0001-5618-2817
Jingxia WuInstitute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, China. jingxia.wu@ihm.ac.cn.ORCID 0009-0001-2559-0065
Xi WangState Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China. xiwang@njmu.edu.cn.ORCID 0000-0002-7572-6354
Guoliang CuiT Cell Metabolism Group (D192), German Cancer Research Center (DKFZ), Heidelberg, Germany. g.cui@dkfz.de.ORCID 0000-0001-5559-7957
German Cancer Research Center · DEHeidelberg University · DENanjing Medical University · CNNational Science Centre · PL
Funding
Boehringer Ingelheim Fonds (Stiftung für medizinische Grundlagenforschung) NACancer Research Institute (CRI) 3914Deutsche Forschungsgemeinschaft (German Research Foundation) 259332240/RTG2099Deutsche Forschungsgemeinschaft (German Research Foundation) CU375/5-2Deutsche Forschungsgemeinschaft (German Research Foundation) CU375/7-1Deutsche Forschungsgemeinschaft (German Research Foundation) CU375/9-1Deutsche Krebshilfe (German Cancer Aid) 70113343Deutsche Krebshilfe (German Cancer Aid) 70114224EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 101045416European Molecular Biology Organization (EMBO) NAHelmholtz Association VH-NG-1113Helmholtz Association ZT0026
Abstract
The malate shuttle is traditionally understood to maintain NAD
Indexed as
Ketoglutaric AcidsNADAmmoniaAntiviral AgentsCD8-Positive T-LymphocytesHumansMalatesOxidation-ReductionPersistent InfectionAmmoniaAntiviral AgentsKetoglutaric AcidsMalatesmalic acidNAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.