ArticleScientific reports2023
Biomaterial composed of chitosan, riboflavin, and hydroxyapatite for bone tissue regeneration.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Electrospun PVA/CS/HA/BA Nanofiber Scaffolds with Enhanced Mechanical Stability and Antifungal Activity for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Article
- Osteoprotective effects of partially defatted house cricket (Acheta domesticus) powder in spontaneously hypertensive rats.PloS one · 2026Article
- Enhanced bone regeneration in critical-size defects using novel ultralong hydroxyapatite microtubes/chitosan composite scaffolds.European journal of medical research · 2025Article
- Strategies and applications of antibacterial surface-modified biomaterials.Bioactive materials · 2025Review
- Silymarin-functionalized nanohydroxyapatite-chitosan nanocomposite: a promising biomaterial for oral health applications.BMC oral health · 2025Article
- Riboflavin as a Dual-Function Additive for Enhancing Biodegradation in Piezoelectric PLA/BT Composites.Materials (Basel, Switzerland) · 2025Article
- Advances in Cryopreservation Strategies for 3D Biofabricated Constructs: From Hydrogels to Bioprinted Tissues.International journal of molecular sciences · 2025Review
- Copper strontium phosphate glasses with high antimicrobial efficacy.Scientific reports · 2025Article
- Enhanced Bioactivity of Chitosan-Alginate-Riboflavin Liquid-Exfoliated Molybdenum Disulfide Nanosheets for Bone Tissue Engineering Applications.ACS omega · 2024Article
- A Review of Chitosan-Based Materials for Biomedical, Food, and Water Treatment Applications.Materials (Basel, Switzerland) · 2024Review
- Polysaccharide Hydroxyapatite (Nano)composites and Their Biomedical Applications: An Overview of Recent Years.ACS omega · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomaterial engineering approaches involve using a combination of miscellaneous bioactive molecules which may promote cell proliferation and, thus, form a scaffold with the environment that favors the regeneration process. Chitosan, a naturally occurring biodegradable polymer, possess some essential features, i.e., biodegradability, biocompatibility, and in the solid phase good porosity, which may contribute to promote cell adhesion. Moreover, doping of the materials with other biocompounds will create a unique and multifunctional scaffold that will be useful in regenerative medicine. This study is focused on the manufacturing and characterization of composite materials based on chitosan, hydroxyapatite, and riboflavin. The resulting films were fabricated by the casting/solvent evaporation method. Morphological and spectroscopy analyses of the films revealed a porous structure and an interconnection between chitosan and apatite. The composite material showed an inhibitory effect on Staphylococcus aureus and exhibited higher antioxidant activity compared to pure chitosan. In vitro studies on riboflavin showed increased cell proliferation and migration of fibroblasts and osteosarcoma cells, thus demonstrating their potential for bone tissue engineering applications.
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