Evidence map›Paper›PMID 37813832›Full record

ArticleNature communications2023

Bone disease imaging through the near-infrared-II window.

Chao Mi, Xun Zhang, Chengyu Yang, Jianqun Wu, Xinxin Chen, Chenguang Ma, Sitong Wu, Zhichao Yang, Pengzhen Qiao, Yang Liu and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 52 citations in OpenAlex.

  1. Review
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  3. Binocular vision fusion enhanced 3D NIR-IIFundamental research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 3 countries.

Chao Mi *UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China. mic@sustech.edu.cn.ORCID http://orcid.org/0000-0003-0895-9948
Xun Zhang *UTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0001-6538-9473
Chengyu YangDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Jianqun WuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Xinxin ChenDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Chenguang MaUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Sitong WuUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Zhichao YangUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Pengzhen QiaoUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Yang LiuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Weijie WuUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Zhiyong GuoUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Jiayan LiaoInstitute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-0616-4762
Jiajia ZhouInstitute for Biomedical Materials and Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-0605-5745
Ming GuanUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.
Chao LiangDepartment of Systems Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China. liangc@sustech.edu.cn.ORCID http://orcid.org/0000-0002-5617-3483
Chao LiuDepartment of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China. liuc33@sustech.edu.cn.ORCID http://orcid.org/0000-0001-6637-1689
Dayong JinUTS-SUSTech Joint Research Centre for Biomedical Materials and Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China. dayong.jin@uts.edu.au.ORCID http://orcid.org/0000-0003-1046-2666
Southern University of Science and Technology · CNUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Optical imaging through the near-infrared-II window (NIR-II, 1000-1700 nm) can penetrate deep tissues without radiation risk, but the targeting of contrast agent is non-specific. Here, we report that lanthanide-doped nanocrystals can passively target the bone marrow, which can be effective for over two months. We therefore develop the high-resolution NIR-II imaging method for bone disease diagnosis, including the 3D bone imaging instrumentation to show the intravital bone morphology. We demonstrate the monitoring of 1 mm bone defects with spatial resolution comparable to the X-ray imaging result. Moreover, NIR-II imaging can reveal the early onset inflammation as the synovitis in the early stage of rheumatoid arthritis, comparable to micro computed tomography (μCT) in diagnosis of osteoarthritis, including the symptoms of osteophyte and hyperostosis in the knee joint.

Indexed as

Bone DiseasesLanthanoid Series ElementsOsteoarthritisBone and BonesHumansOptical ImagingX-Ray MicrotomographyLanthanoid Series Elements

Identifiers

PMID37813832
PMCPMC10562434
OpenAlexW4387451591

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.